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10.1083/jcb.202108015 http://scihub22266oqcxt.onion/10.1083/jcb.202108015 35674692!9184850!35674692     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35674692&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biol 2022 ; 221 (7): ä Nephropedia Template TP {{tp|p=35674692|t=2022. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity |pdf=|usr=}}{{35674692}} gab.com Text SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35674692 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are symptoms of COVID-19, and may be related to cilia dysfunction. Here, we found that the SARS-CoV-2 ORF10 increases the overall E3 ligase activity of the CUL2ZYG11B complex by interacting with ZYG11B. Enhanced CUL2ZYG11B activity by ORF10 causes increased ubiquitination and subsequent proteasome-mediated degradation of an intraflagellar transport (IFT) complex B protein, IFT46, thereby impairing both cilia biogenesis and maintenance. Further, we show that exposure of the respiratory tract of hACE2 mice to SARS-CoV-2 or SARS-CoV-2 ORF10 alone results in cilia-dysfunction-related phenotypes, and the ORF10 expression in primary human nasal epithelial cells (HNECs) also caused a rapid loss of the ciliary layer. Our study demonstrates how SARS-CoV-2 ORF10 hijacks CUL2ZYG11B to eliminate IFT46 and leads to cilia dysfunction, thereby offering a powerful etiopathological explanation for how SARS-CoV-2 causes multiple cilia-dysfunction-related symptoms specific to COVID-19. Twit Text FOAVip SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35674692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35674692 #FOAvip English Wikipedia <ref>{{Cite pmid|35674692}}</ref> SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity #MMPMID35674692 Wang L; Liu C; Yang B; Zhang H; Jiao J; Zhang R; Liu S; Xiao S; Chen Y; Liu B; Ma Y; Duan X; Guo Y; Guo M; Wu B; Wang X; Huang X; Yang H; Gui Y; Fang M; Zhang L; Duo S; Guo X; Li W J Cell Biol 2022[Jul]; 221 (7): ä PMID35674692show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal pathogen of the ongoing global pandemic of coronavirus disease 2019 (COVID-19). Loss of smell and taste are symptoms of COVID-19, and may be related to cilia dysfunction. Here, we found that the SARS-CoV-2 ORF10 increases the overall E3 ligase activity of the CUL2ZYG11B complex by interacting with ZYG11B. Enhanced CUL2ZYG11B activity by ORF10 causes increased ubiquitination and subsequent proteasome-mediated degradation of an intraflagellar transport (IFT) complex B protein, IFT46, thereby impairing both cilia biogenesis and maintenance. Further, we show that exposure of the respiratory tract of hACE2 mice to SARS-CoV-2 or SARS-CoV-2 ORF10 alone results in cilia-dysfunction-related phenotypes, and the ORF10 expression in primary human nasal epithelial cells (HNECs) also caused a rapid loss of the ciliary layer. Our study demonstrates how SARS-CoV-2 ORF10 hijacks CUL2ZYG11B to eliminate IFT46 and leads to cilia dysfunction, thereby offering a powerful etiopathological explanation for how SARS-CoV-2 causes multiple cilia-dysfunction-related symptoms specific to COVID-19. |*Cilia/metabolism/pathology[MESH] |*SARS-CoV-2/pathogenicity[MESH] |*Ubiquitin-Protein Ligases/metabolism[MESH] |Animals[MESH] |Cells, Cultured[MESH] |Cytoskeletal Proteins[MESH] |Epithelial Cells/metabolism/virology[MESH] |Humans[MESH] |Mice[MESH]SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity (epmc).pdf DeepDyve Pubget Overpricing