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10.7554/eLife.74443 http://scihub22266oqcxt.onion/10.7554/eLife.74443 35666101!9262386!35666101     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2022 ; 11 (ä): ä Nephropedia Template TP {{tp|p=35666101|t=2022. Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells |pdf=|usr=}}{{35666101}} gab.com Text Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=35666101 #FOAvip COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity of macrophages allows this cell type to promote pathogen elimination and inflammation or suppress inflammation and promote tissue remodeling and injury repair. During an infection, the clearance of dead and dying cells, a process named efferocytosis, can modulate the interplay between these contrasting functions. Here, we show that engulfment of SARS-CoV-2-infected apoptotic cells exacerbates inflammatory cytokine production, inhibits the expression of efferocytic receptors, and impairs continual efferocytosis by macrophages. We also provide evidence supporting that lung monocytes and macrophages from severe COVID-19 patients have compromised efferocytic capacity. Our findings reveal that dysfunctional efferocytosis of SARS-CoV-2-infected cell corpses suppresses macrophage anti-inflammation and efficient tissue repair programs and provides mechanistic insights for the excessive production of pro-inflammatory cytokines and accumulation of tissue damage associated with COVID-19 immunopathogenesis. Twit Text FOAVip Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=35666101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35666101 #FOAvip English Wikipedia <ref>{{Cite pmid|35666101}}</ref> Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells #MMPMID35666101 Salina ACG; Dos-Santos D; Rodrigues TS; Fortes-Rocha M; Freitas-Filho EG; Alzamora-Terrel DL; Castro IMS; Fraga da Silva TFC; de Lima MHF; Nascimento DC; Silva CM; Toller-Kawahisa JE; Becerra A; Oliveira S; Caetite DB; Almeida L; Ishimoto AY; Lima TM; Martins RB; Veras F; do Amaral NB; Giannini MC; Bonjorno LP; Lopes MIF; Benatti MN; Batah SS; Santana RC; Vilar FC; Martins MA; Assad RL; de Almeida SCL; de Oliveira FR; Arruda Neto E; Cunha TM; Alves-Filho JC; Bonato VLD; Cunha FQ; Fabro AT; Nakaya HI; Zamboni DS; Louzada-Junior P; Oliveira RDR; Cunha LD Elife 2022[Jun]; 11 (ä): ä PMID35666101show ga COVID-19 is a disease of dysfunctional immune responses, but the mechanisms triggering immunopathogenesis are not established. The functional plasticity of macrophages allows this cell type to promote pathogen elimination and inflammation or suppress inflammation and promote tissue remodeling and injury repair. During an infection, the clearance of dead and dying cells, a process named efferocytosis, can modulate the interplay between these contrasting functions. Here, we show that engulfment of SARS-CoV-2-infected apoptotic cells exacerbates inflammatory cytokine production, inhibits the expression of efferocytic receptors, and impairs continual efferocytosis by macrophages. We also provide evidence supporting that lung monocytes and macrophages from severe COVID-19 patients have compromised efferocytic capacity. Our findings reveal that dysfunctional efferocytosis of SARS-CoV-2-infected cell corpses suppresses macrophage anti-inflammation and efficient tissue repair programs and provides mechanistic insights for the excessive production of pro-inflammatory cytokines and accumulation of tissue damage associated with COVID-19 immunopathogenesis. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Anti-Inflammatory Agents/pharmacology[MESH] |Apoptosis[MESH] |Humans[MESH] |Macrophages/metabolism[MESH]Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage a(epmc).pdf DeepDyve Pubget Overpricing