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10.1016/j.diabet.2022.101359 http://scihub22266oqcxt.onion/10.1016/j.diabet.2022.101359 35662580!9154087!35662580     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab 2022 ; 48 (4): 101359 Nephropedia Template TP {{tp|p=35662580|t=2022. Protection by metformin against severe Covid-19: An in-depth mechanistic analysis |pdf=|usr=}}{{35662580}} gab.com Text Protection by metformin against severe Covid-19: An in-depth mechanistic analysis JO: Diabetes Metab http://www.kidney.de/pget.php?&tw=1&pmid=35662580 #FOAvip Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19 have reported a favourable association between metformin and Covid-19-related outcomes in patients with type 2 diabetes mellitus (T2DM). This is not surprising since metformin affects many of the pathophysiological mechanisms implicated in SARS-CoV-2 immune response, systemic spread and sequelae. A comparison of the multifactorial pathophysiological mechanisms of Covid-19 progression with metformin's well-known pleiotropic properties suggests that the treatment of patients with this drug might be particularly beneficial. Indeed, metformin could alleviate the cytokine storm, diminish virus entry into cells, protect against microvascular damage as well as prevent secondary fibrosis. Although our in-depth analysis covers many potential metformin mechanisms of action, we want to highlight more particularly its unique microcirculatory protective effects since worsening of Covid-19 disease clearly appears as largely due to severe defects in the structure and functioning of microvessels. Overall, these observations confirm that metformin is a unique, pleiotropic drug that targets many of Covid-19's pathophysiology processes in a diabetes-independent manner. Twit Text FOAVip Protection by metformin against severe Covid-19: An in-depth mechanistic analysis ????Diabetes Metab http://www.kidney.de/pget.php?&tw=1&pmid=35662580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35662580 #FOAvip English Wikipedia <ref>{{Cite pmid|35662580}}</ref> Protection by metformin against severe Covid-19: An in-depth mechanistic analysis #MMPMID35662580 Wiernsperger N; Al-Salameh A; Cariou B; Lalau JD Diabetes Metab 2022[Jul]; 48 (4): 101359 PMID35662580show ga Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19 have reported a favourable association between metformin and Covid-19-related outcomes in patients with type 2 diabetes mellitus (T2DM). This is not surprising since metformin affects many of the pathophysiological mechanisms implicated in SARS-CoV-2 immune response, systemic spread and sequelae. A comparison of the multifactorial pathophysiological mechanisms of Covid-19 progression with metformin's well-known pleiotropic properties suggests that the treatment of patients with this drug might be particularly beneficial. Indeed, metformin could alleviate the cytokine storm, diminish virus entry into cells, protect against microvascular damage as well as prevent secondary fibrosis. Although our in-depth analysis covers many potential metformin mechanisms of action, we want to highlight more particularly its unique microcirculatory protective effects since worsening of Covid-19 disease clearly appears as largely due to severe defects in the structure and functioning of microvessels. Overall, these observations confirm that metformin is a unique, pleiotropic drug that targets many of Covid-19's pathophysiology processes in a diabetes-independent manner. |*COVID-19[MESH] |*Diabetes Mellitus, Type 2/complications/drug therapy[MESH] |*Metformin/therapeutic use[MESH] |Humans[MESH] |Microcirculation[MESH]Protection by metformin against severe Covid-19: An in-depth mechanist(epmc).pdf DeepDyve Pubget Overpricing