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10.1038/s41589-022-01060-0 http://scihub22266oqcxt.onion/10.1038/s41589-022-01060-0 35654847!9512702!35654847     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Chem+Biol 2022 ; 18 (10): 1046-1055 Nephropedia Template TP {{tp|p=35654847|t=2022. A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein |pdf=|usr=}}{{35654847}} gab.com Text A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=35654847 #FOAvip Protein tertiary structure mimetics are valuable tools to target large protein-protein interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin motifs from a previously reported three-helix-bundle miniprotein that targets the receptor-binding domain (RBD) of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Through truncation of the third helix and optimization of the interhelical loop residues of the miniprotein, we developed a thermostable dimeric helix-hairpin. The dimeric four-helix bundle competes with the human angiotensin-converting enzyme 2 (ACE2) in binding to RBD with 2:2 stoichiometry. Cryogenic-electron microscopy revealed the formation of dimeric spike ectodomain trimer by the four-helix bundle, where all the three RBDs from either spike protein are attached head-to-head in an open conformation, revealing a novel mechanism for virus neutralization. The proteomimetic protects hamsters from high dose viral challenge with replicative SARS-CoV-2 viruses, demonstrating the promise of this class of peptides that inhibit protein-protein interaction through target dimerization. Twit Text FOAVip A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=35654847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35654847 #FOAvip English Wikipedia <ref>{{Cite pmid|35654847}}</ref> A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein #MMPMID35654847 Khatri B; Pramanick I; Malladi SK; Rajmani RS; Kumar S; Ghosh P; Sengupta N; Rahisuddin R; Kumar N; Kumaran S; Ringe RP; Varadarajan R; Dutta S; Chatterjee J Nat Chem Biol 2022[Oct]; 18 (10): 1046-1055 PMID35654847show ga Protein tertiary structure mimetics are valuable tools to target large protein-protein interaction interfaces. Here, we demonstrate a strategy for designing dimeric helix-hairpin motifs from a previously reported three-helix-bundle miniprotein that targets the receptor-binding domain (RBD) of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Through truncation of the third helix and optimization of the interhelical loop residues of the miniprotein, we developed a thermostable dimeric helix-hairpin. The dimeric four-helix bundle competes with the human angiotensin-converting enzyme 2 (ACE2) in binding to RBD with 2:2 stoichiometry. Cryogenic-electron microscopy revealed the formation of dimeric spike ectodomain trimer by the four-helix bundle, where all the three RBDs from either spike protein are attached head-to-head in an open conformation, revealing a novel mechanism for virus neutralization. The proteomimetic protects hamsters from high dose viral challenge with replicative SARS-CoV-2 viruses, demonstrating the promise of this class of peptides that inhibit protein-protein interaction through target dimerization. |*Angiotensin-Converting Enzyme 2[MESH] |*COVID-19[MESH] |Dimerization[MESH] |Humans[MESH] |Peptides/metabolism[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH]A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing th(epmc).pdf DeepDyve Pubget Overpricing