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10.1093/infdis/jiac218

http://scihub22266oqcxt.onion/10.1093/infdis/jiac218
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35639922!9213855!35639922
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suck abstract from ncbi


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pmid35639922      J+Infect+Dis 2022 ; 226 (12): 2137-2141
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  • A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients #MMPMID35639922
  • Fahnoe U; Ronit A; Berg RMG; Jorgensen SE; Mogensen TH; Underwood AP; Scheel TKH; Bukh J; Plovsing RR
  • J Infect Dis 2022[Dec]; 226 (12): 2137-2141 PMID35639922show ga
  • The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19-associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (with or without DXM) and 8 non-COVID-19 critically ill controls. CARDS with DXM was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis, and FC-gamma receptor signaling. Most interferon-stimulated genes were upregulated in CARDS, particularly in CARDS without DXM. In conclusion, DXM treatment was not associated with regulation of proinflammatory pathways in CARDS but with regulation of other local immune responses. Clinical Trials Registration. NCT04354584.
  • |*COVID-19/genetics[MESH]
  • |*Pneumonia[MESH]
  • |*Respiratory Distress Syndrome/drug therapy[MESH]
  • |Bronchoalveolar Lavage Fluid[MESH]
  • |Dexamethasone/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Lung[MESH]


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