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10.1093/infdis/jiac218 http://scihub22266oqcxt.onion/10.1093/infdis/jiac218 35639922!9213855!35639922     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35639922.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Infect+Dis 2022 ; 226 (12): 2137-2141 Nephropedia Template TP {{tp|p=35639922|t=2022. A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients |pdf=|usr=}}{{35639922}} gab.com Text A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35639922 #FOAvip The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19-associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (with or without DXM) and 8 non-COVID-19 critically ill controls. CARDS with DXM was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis, and FC-gamma receptor signaling. Most interferon-stimulated genes were upregulated in CARDS, particularly in CARDS without DXM. In conclusion, DXM treatment was not associated with regulation of proinflammatory pathways in CARDS but with regulation of other local immune responses. Clinical Trials Registration. NCT04354584. Twit Text FOAVip A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=35639922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35639922 #FOAvip English Wikipedia <ref>{{Cite pmid|35639922}}</ref> A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lungs of COVID-19 Patients #MMPMID35639922 Fahnoe U; Ronit A; Berg RMG; Jorgensen SE; Mogensen TH; Underwood AP; Scheel TKH; Bukh J; Plovsing RR J Infect Dis 2022[Dec]; 226 (12): 2137-2141 PMID35639922show ga The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19-associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (with or without DXM) and 8 non-COVID-19 critically ill controls. CARDS with DXM was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis, and FC-gamma receptor signaling. Most interferon-stimulated genes were upregulated in CARDS, particularly in CARDS without DXM. In conclusion, DXM treatment was not associated with regulation of proinflammatory pathways in CARDS but with regulation of other local immune responses. Clinical Trials Registration. NCT04354584. |*COVID-19/genetics[MESH] |*Pneumonia[MESH] |*Respiratory Distress Syndrome/drug therapy[MESH] |Bronchoalveolar Lavage Fluid[MESH] |Dexamethasone/pharmacology/therapeutic use[MESH] |Humans[MESH] |Lung[MESH]A Distinct Dexamethasone-Dependent Gene Expression Profile in the Lung(epmc).pdf DeepDyve Pubget Overpricing