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10.3390/v14051042

http://scihub22266oqcxt.onion/10.3390/v14051042
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35632784!9143223!35632784
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suck abstract from ncbi


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pmid35632784      Viruses 2022 ; 14 (5): ä
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  • Clearance of Persistent SARS-CoV-2 RNA Detection in a NFkappaB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report #MMPMID35632784
  • Sabino JS; Amorim MR; de Souza WM; Marega LF; Mofatto LS; Toledo-Teixeira DA; Forato J; Stabeli RG; Costa ML; Spilki FR; Sabino EC; Faria NR; Benites BD; Addas-Carvalho M; Stucchi RSB; Vasconcelos DM; Weaver SC; Granja F; Proenca-Modena JL; Vilela MMDS
  • Viruses 2022[May]; 14 (5): ä PMID35632784show ga
  • Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFkappaB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.
  • |*COVID-19/complications[MESH]
  • |*SARS-CoV-2/genetics[MESH]
  • |Antibodies, Viral[MESH]
  • |Eating[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A[MESH]
  • |Immunoglobulin G[MESH]
  • |Milk, Human[MESH]
  • |NF-kappa B[MESH]
  • |Post-Acute COVID-19 Syndrome[MESH]


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