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10.3390/v14050999

http://scihub22266oqcxt.onion/10.3390/v14050999
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35632741!9146335!35632741
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suck abstract from ncbi


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pmid35632741      Viruses 2022 ; 14 (5): ä
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  • SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions #MMPMID35632741
  • Planes R; Bert JB; Tairi S; BenMohamed L; Bahraoui E
  • Viruses 2022[May]; 14 (5): ä PMID35632741show ga
  • This paper presents a molecular characterization of the interaction between the SARS-CoV-2 envelope (E) protein and TLR2. We demonstrated that the E protein, both as a recombinant soluble protein and as a native membrane protein associated with SARS-CoV-2 viral particles, interacts physically with the TLR2 receptor in a specific and dose-dependent manner. Furthermore, we showed that the specific interaction with the TLR2 pathway activates the NF-kappaB transcription factor and stimulates the production of the CXCL8 inflammatory chemokine. In agreement with the importance of NF-kappaB in the TLR signaling pathway, we showed that the chemical inhibition of this transcription factor leads to significant inhibition of CXCL8 production, while the blockade of the P38 and ERK1/2 MAP kinases only results in partial CXCL8 inhibition. Overall, our findings propose the envelope (E) protein as a novel molecular target for COVID-19 interventions: either (i) by exploring the therapeutic effect of anti-E blocking/neutralizing antibodies in symptomatic COVID-19 patients, or (ii) as a promising non-spike SARS-CoV-2 antigen candidate for inclusion in the development of next-generation prophylactic vaccines against COVID-19 infection and disease.
  • |*COVID-19[MESH]
  • |*Coronavirus Envelope Proteins/metabolism[MESH]
  • |*SARS-CoV-2[MESH]
  • |*Toll-Like Receptor 2/metabolism[MESH]
  • |Humans[MESH]
  • |Interleukin-8[MESH]


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