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10.3390/v14050983 http://scihub22266oqcxt.onion/10.3390/v14050983 35632725!9143006!35632725     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35632725.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2022 ; 14 (5): ä Nephropedia Template TP {{tp|p=35632725|t=2022. SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE |pdf=|usr=}}{{35632725}} gab.com Text SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35632725 #FOAvip Clinical studies indicate that patients infected with SARS-CoV-2 develop hyperinflammation, which correlates with increased mortality. The SARS-CoV-2/COVID-19-dependent inflammation is thought to occur via increased cytokine production and hyperactivity of RAGE in several cell types, a phenomenon observed for other disorders and diseases. Metabolic reprogramming has been shown to contribute to inflammation and is considered a hallmark of cancer, neurodegenerative diseases, and viral infections. Malfunctioning glycolysis, which normally aims to convert glucose into pyruvate, leads to the accumulation of advanced glycation end products (AGEs). Being aberrantly generated, AGEs then bind to their receptor, RAGE, and activate several pro-inflammatory genes, such as IL-1b and IL-6, thus, increasing hypoxia and inducing senescence. Using the lung epithelial cell (BEAS-2B) line, we demonstrated that SARS-CoV-2 proteins reprogram the cellular metabolism and increase pyruvate kinase muscle isoform 2 (PKM2). This deregulation promotes the accumulation of AGEs and senescence induction. We showed the ability of the PKM2 stabilizer, Tepp-46, to reverse the observed glycolysis changes/alterations and restore this essential metabolic process. Twit Text FOAVip SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35632725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35632725 #FOAvip English Wikipedia <ref>{{Cite pmid|35632725}}</ref> SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE #MMPMID35632725 Allen CNS; Santerre M; Arjona SP; Ghaleb LJ; Herzi M; Llewellyn MD; Shcherbik N; Sawaya BE Viruses 2022[May]; 14 (5): ä PMID35632725show ga Clinical studies indicate that patients infected with SARS-CoV-2 develop hyperinflammation, which correlates with increased mortality. The SARS-CoV-2/COVID-19-dependent inflammation is thought to occur via increased cytokine production and hyperactivity of RAGE in several cell types, a phenomenon observed for other disorders and diseases. Metabolic reprogramming has been shown to contribute to inflammation and is considered a hallmark of cancer, neurodegenerative diseases, and viral infections. Malfunctioning glycolysis, which normally aims to convert glucose into pyruvate, leads to the accumulation of advanced glycation end products (AGEs). Being aberrantly generated, AGEs then bind to their receptor, RAGE, and activate several pro-inflammatory genes, such as IL-1b and IL-6, thus, increasing hypoxia and inducing senescence. Using the lung epithelial cell (BEAS-2B) line, we demonstrated that SARS-CoV-2 proteins reprogram the cellular metabolism and increase pyruvate kinase muscle isoform 2 (PKM2). This deregulation promotes the accumulation of AGEs and senescence induction. We showed the ability of the PKM2 stabilizer, Tepp-46, to reverse the observed glycolysis changes/alterations and restore this essential metabolic process. |*COVID-19[MESH] |*Pneumonia[MESH] |Humans[MESH] |Inflammation[MESH] |Pyridazines[MESH] |Pyrroles[MESH]SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming an(epmc).pdf DeepDyve Pubget Overpricing