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10.1042/CS20210879 http://scihub22266oqcxt.onion/10.1042/CS20210879 35621124!9429452!35621124     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35621124.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Sci+(Lond) 2022 ; 136 (10): 747-769 Nephropedia Template TP {{tp|p=35621124|t=2022. Pathogenesis of pneumonia and acute lung injury |pdf=|usr=}}{{35621124}} gab.com Text Pathogenesis of pneumonia and acute lung injury JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=35621124 #FOAvip Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary and critical care healthcare professionals, and these challenges have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One limitation to translational investigation of acute lung injury, including its most severe manifestation (acute respiratory distress syndrome, ARDS) has been heterogeneity resulting from the clinical and physiologic diagnosis that represents a wide variety of etiologies. Recent efforts have improved our understanding and approach to heterogeneity by defining sub-phenotypes of ARDS although significant gaps in knowledge remain. Improving our mechanistic understanding of acute lung injury and its most common cause, infectious pneumonia, can advance our approach to precision targeted clinical interventions. Here, we review the pathogenesis of pneumonia and acute lung injury, including how respiratory infections and lung injury disrupt lung homoeostasis, and provide an overview of respiratory microbial pathogenesis, the lung microbiome, and interventions that have been demonstrated to improve outcomes-or not-in human clinical trials. Twit Text FOAVip Pathogenesis of pneumonia and acute lung injury ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=35621124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35621124 #FOAvip English Wikipedia <ref>{{Cite pmid|35621124}}</ref> Pathogenesis of pneumonia and acute lung injury #MMPMID35621124 Long ME; Mallampalli RK; Horowitz JC Clin Sci (Lond) 2022[May]; 136 (10): 747-769 PMID35621124show ga Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary and critical care healthcare professionals, and these challenges have recently garnered global attention due to the ongoing Sars-CoV-2 pandemic. One limitation to translational investigation of acute lung injury, including its most severe manifestation (acute respiratory distress syndrome, ARDS) has been heterogeneity resulting from the clinical and physiologic diagnosis that represents a wide variety of etiologies. Recent efforts have improved our understanding and approach to heterogeneity by defining sub-phenotypes of ARDS although significant gaps in knowledge remain. Improving our mechanistic understanding of acute lung injury and its most common cause, infectious pneumonia, can advance our approach to precision targeted clinical interventions. Here, we review the pathogenesis of pneumonia and acute lung injury, including how respiratory infections and lung injury disrupt lung homoeostasis, and provide an overview of respiratory microbial pathogenesis, the lung microbiome, and interventions that have been demonstrated to improve outcomes-or not-in human clinical trials. |*Acute Lung Injury/etiology/pathology[MESH] |*COVID-19[MESH] |*Pneumonia[MESH] |*Respiratory Distress Syndrome/etiology[MESH] |Humans[MESH]Pathogenesis of pneumonia and acute lung injury (epmc).pdf DeepDyve Pubget Overpricing