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10.1172/jci.insight.156372 http://scihub22266oqcxt.onion/10.1172/jci.insight.156372 35608920!9310533!35608920     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35608920&cmd=llinks): Failed to open stream: HTTP request failed! 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Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses |pdf=|usr=}}{{35608920}} gab.com Text Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35608920 #FOAvip The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcomes with coronavirus disease 2019 (COVID-19) is that the immune response to the SARS-CoV-2 spike protein is enriched for antibodies directed against epitopes shared with endemic beta-coronaviruses and has a lower proportion of antibodies targeting the more protective variable regions of the spike. The magnitude of antibody responses to the SARS-CoV-2 full-length spike protein, its domains and subunits, and the SARS-CoV-2 nucleocapsid also correlated strongly with responses to the endemic beta-coronavirus spike proteins in individuals admitted to an intensive care unit (ICU) with fatal COVID-19 outcomes, but not in individuals with nonfatal outcomes. This correlation was found to be due to the antibody response directed at the S2 subunit of the SARS-CoV-2 spike protein, which has the highest degree of conservation between the beta-coronavirus spike proteins. Intriguingly, antibody responses to the less cross-reactive SARS-CoV-2 nucleocapsid were not significantly different in individuals who were admitted to an ICU with fatal and nonfatal outcomes, suggesting an antibody profile in individuals with fatal outcomes consistent with an "original antigenic sin" type response. Twit Text FOAVip Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35608920 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35608920 #FOAvip English Wikipedia <ref>{{Cite pmid|35608920}}</ref> Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses #MMPMID35608920 McNaughton AL; Paton RS; Edmans M; Youngs J; Wellens J; Phalora P; Fyfe A; Belij-Rammerstorfer S; Bolton JS; Ball J; Carnell GW; Dejnirattisai W; Dold C; Eyre DW; Hopkins P; Howarth A; Kooblall K; Klim H; Leaver S; Lee LN; Lopez-Camacho C; Lumley SF; Macallan DC; Mentzer AJ; Provine NM; Ratcliff J; Slon-Compos J; Skelly D; Stolle L; Supasa P; Temperton N; Walker C; Wang B; Wyncoll D; Simmonds P; Lambe T; Baillie JK; Semple MG; Openshaw PJ; Obolski U; Turner M; Carroll M; Mongkolsapaya J; Screaton G; Kennedy SH; Jarvis L; Barnes E; Dunachie S; Lourenco J; Matthews PC; Bicanic T; Klenerman P; Gupta S; Thompson CP JCI Insight 2022[Jul]; 7 (13): ä PMID35608920show ga The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of fatal outcomes with coronavirus disease 2019 (COVID-19) is that the immune response to the SARS-CoV-2 spike protein is enriched for antibodies directed against epitopes shared with endemic beta-coronaviruses and has a lower proportion of antibodies targeting the more protective variable regions of the spike. The magnitude of antibody responses to the SARS-CoV-2 full-length spike protein, its domains and subunits, and the SARS-CoV-2 nucleocapsid also correlated strongly with responses to the endemic beta-coronavirus spike proteins in individuals admitted to an intensive care unit (ICU) with fatal COVID-19 outcomes, but not in individuals with nonfatal outcomes. This correlation was found to be due to the antibody response directed at the S2 subunit of the SARS-CoV-2 spike protein, which has the highest degree of conservation between the beta-coronavirus spike proteins. Intriguingly, antibody responses to the less cross-reactive SARS-CoV-2 nucleocapsid were not significantly different in individuals who were admitted to an ICU with fatal and nonfatal outcomes, suggesting an antibody profile in individuals with fatal outcomes consistent with an "original antigenic sin" type response. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus[MESH] |Antibodies, Viral[MESH] |Antibody Formation[MESH] |Epitopes[MESH] |Humans[MESH]Fatal COVID-19 outcomes are associated with an antibody response targe(epmc).pdf DeepDyve Pubget Overpricing