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10.1007/s10072-022-06136-2

http://scihub22266oqcxt.onion/10.1007/s10072-022-06136-2
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suck abstract from ncbi


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pmid35608736      Neurol+Sci 2022 ; 43 (8): 4635-4643
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  • Autonomic dysfunction in non-critically ill COVID-19 patients during the acute phase of disease: an observational, cross-sectional study #MMPMID35608736
  • Scala I; Bellavia S; Luigetti M; Brunetti V; Broccolini A; Gabrielli M; Zileri Dal Verme L; Calabresi P; Della Marca G; Frisullo G
  • Neurol Sci 2022[Aug]; 43 (8): 4635-4643 PMID35608736show ga
  • INTRODUCTION: Evidence is emerging about an extra-pulmonary involvement of SARS-CoV-2, including the nervous system. Autonomic dysfunction in patients recovering from acute coronavirus disease 2019 (COVID-19) has been recently described. Dysautonomic symptoms have been reported in the acute phase of the disease, but clear evidence is lacking, especially in the non-critical forms of the infection. OBJECTIVE: The aim of this study is to assess the prevalence of dysautonomia in acute, non-critically ill COVID-19 patients. METHODS: In this observational, cross-sectional study, we compared 38 non-critically ill patients with acute COVID-19 (COVID + group) to 38 healthy volunteers (COVID - group) in order to assess the prevalence of signs and symptoms of dysautonomia through the administration of the composite autonomic symptom score 31 (COMPASS-31) and an active standing test. Comparisons between groups were performed by means of both univariate and multivariate analyses. RESULTS: The prevalence of orthostatic hypotension was significantly higher in the COVID + group. Higher total scores of COMPASS-31 were observed in the COVID + group than controls. Significant differences between groups emerged in the secretomotor, orthostatic intolerance, and gastrointestinal COMPASS-31 domains. All these results maintained the statistical significance after the adjustment for concomitant drugs with a known effect on the autonomic nervous system assumed by the study participants, except for the differences in the gastrointestinal domain of COMPASS-31. CONCLUSION: Our results suggest that an autonomic dysfunction could be an early manifestation of COVID-19, even in the contest of mild forms of the infection.
  • |*Autonomic Nervous System Diseases/diagnosis[MESH]
  • |*COVID-19/complications[MESH]
  • |*Orthostatic Intolerance[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Humans[MESH]


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