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10.1148/radiol.220069 http://scihub22266oqcxt.onion/10.1148/radiol.220069 35608443!9134268!35608443     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35608443.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Radiology 2022 ; 305 (3): 709-717 Nephropedia Template TP {{tp|p=35608443|t=2022. Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID |pdf=|usr=}}{{35608443}} gab.com Text Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID JO: Radiology http://www.kidney.de/pget.php?&tw=1&pmid=35608443 #FOAvip Background Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. Purpose To determine if the previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 ((129)Xe) MRI scans in participants with post-COVID-19 condition who were hospitalized are also present in participants with post-COVID-19 condition who were not hospitalized. Materials and Methods In this prospective study, nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) were enrolled from June 2020 to August 2021. Participants underwent chest CT, HP (129)Xe MRI, pulmonary function testing, and the 1-minute sit-to-stand test and completed breathlessness questionnaires. Control subjects underwent HP (129)Xe MRI only. CT scans were analyzed for post-COVID-19 interstitial lung disease severity using a previously published scoring system and full-scale airway network (FAN) modeling. Analysis used group and pairwise comparisons between participants and control subjects and correlations between participant clinical and imaging data. Results A total of 11 NHLC participants (four men, seven women; mean age, 44 years +/- 11 [SD]; 95% CI: 37, 50) and 12 PHC participants (10 men, two women; mean age, 58 years +/-10; 95% CI: 52, 64) were included, with a significant difference in age between groups (P = .05). Mean time from infection was 287 days +/- 79 (95% CI: 240, 334) and 143 days +/- 72 (95% CI: 105, 190) in NHLC and PHC participants, respectively. NHLC and PHC participants had normal or near normal CT scans (mean, 0.3/25 +/- 0.6 [95% CI: 0, 0.63] and 7/25 +/- 5 [95% CI: 4, 10], respectively). Gas transfer (Dlco) was different between NHLC and PHC participants (mean Dlco, 76% +/- 8 [95% CI: 73, 83] vs 86% +/- 8 [95% CI: 80, 91], respectively; P = .04), but there was no evidence of other differences in lung function. Mean red blood cell-to-tissue plasma ratio was different between volunteers (mean, 0.45 +/- 0.07; 95% CI: 0.43, 0.47]) and PHC participants (mean, 0.31 +/- 0.10; 95% CI: 0.24, 0.37; P = .02) and between volunteers and NHLC participants (mean, 0.37 +/- 0.10; 95% CI: 0.31, 0.44; P = .03) but not between NHLC and PHC participants (P = .26). FAN results did not correlate with Dlco) or HP (129)Xe MRI results. Conclusion Nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) showed hyperpolarized pulmonary xenon 129 MRI and red blood cell-to-tissue plasma abnormalities, with NHLC participants demonstrating lower gas transfer than PHC participants despite having normal CT findings. (c) RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Parraga and Matheson in this issue. Twit Text FOAVip Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID ????Radiology http://www.kidney.de/pget.php?&tw=1&pmid=35608443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35608443 #FOAvip English Wikipedia <ref>{{Cite pmid|35608443}}</ref> Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patients with Long COVID #MMPMID35608443 Grist JT; Collier GJ; Walters H; Kim M; Chen M; Abu Eid G; Laws A; Matthews V; Jacob K; Cross S; Eves A; Durrant M; McIntyre A; Thompson R; Schulte RF; Raman B; Robbins PA; Wild JM; Fraser E; Gleeson F Radiology 2022[Dec]; 305 (3): 709-717 PMID35608443show ga Background Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. Purpose To determine if the previously described lung abnormalities seen on hyperpolarized (HP) pulmonary xenon 129 ((129)Xe) MRI scans in participants with post-COVID-19 condition who were hospitalized are also present in participants with post-COVID-19 condition who were not hospitalized. Materials and Methods In this prospective study, nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) were enrolled from June 2020 to August 2021. Participants underwent chest CT, HP (129)Xe MRI, pulmonary function testing, and the 1-minute sit-to-stand test and completed breathlessness questionnaires. Control subjects underwent HP (129)Xe MRI only. CT scans were analyzed for post-COVID-19 interstitial lung disease severity using a previously published scoring system and full-scale airway network (FAN) modeling. Analysis used group and pairwise comparisons between participants and control subjects and correlations between participant clinical and imaging data. Results A total of 11 NHLC participants (four men, seven women; mean age, 44 years +/- 11 [SD]; 95% CI: 37, 50) and 12 PHC participants (10 men, two women; mean age, 58 years +/-10; 95% CI: 52, 64) were included, with a significant difference in age between groups (P = .05). Mean time from infection was 287 days +/- 79 (95% CI: 240, 334) and 143 days +/- 72 (95% CI: 105, 190) in NHLC and PHC participants, respectively. NHLC and PHC participants had normal or near normal CT scans (mean, 0.3/25 +/- 0.6 [95% CI: 0, 0.63] and 7/25 +/- 5 [95% CI: 4, 10], respectively). Gas transfer (Dlco) was different between NHLC and PHC participants (mean Dlco, 76% +/- 8 [95% CI: 73, 83] vs 86% +/- 8 [95% CI: 80, 91], respectively; P = .04), but there was no evidence of other differences in lung function. Mean red blood cell-to-tissue plasma ratio was different between volunteers (mean, 0.45 +/- 0.07; 95% CI: 0.43, 0.47]) and PHC participants (mean, 0.31 +/- 0.10; 95% CI: 0.24, 0.37; P = .02) and between volunteers and NHLC participants (mean, 0.37 +/- 0.10; 95% CI: 0.31, 0.44; P = .03) but not between NHLC and PHC participants (P = .26). FAN results did not correlate with Dlco) or HP (129)Xe MRI results. Conclusion Nonhospitalized participants with post-COVID-19 condition (NHLC) and posthospitalized participants with post-COVID-19 condition (PHC) showed hyperpolarized pulmonary xenon 129 MRI and red blood cell-to-tissue plasma abnormalities, with NHLC participants demonstrating lower gas transfer than PHC participants despite having normal CT findings. (c) RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Parraga and Matheson in this issue. |*COVID-19/diagnostic imaging[MESH] |*Xenon Isotopes[MESH] |Adult[MESH] |Dyspnea[MESH] |Female[MESH] |Humans[MESH] |Lung/diagnostic imaging[MESH] |Magnetic Resonance Imaging/methods[MESH] |Male[MESH] |Middle Aged[MESH] |Post-Acute COVID-19 Syndrome[MESH]Lung Abnormalities Detected with Hyperpolarized (129)Xe MRI in Patient(epmc).pdf DeepDyve Pubget Overpricing