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10.1021/acs.jpclett.2c01102 http://scihub22266oqcxt.onion/10.1021/acs.jpclett.2c01102 35593652!ä!35593652 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Phys+Chem+Lett 2022 ; 13 (21): 4642-4649 Nephropedia Template TP {{tp|p=35593652|t=2022. Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome Coronavirus-2 Permeabilization and Polarization of the Host Lipid Membrane by Viroporins |pdf=|usr=}}{{35593652}} gab.com Text Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome Coronavirus-2 Permeabilization and Polarization of the Host Lipid Membrane by Viroporins JO: J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=35593652 #FOAvip Like all viral infections, SARS-CoV-2 acts at multiple levels, hijacking fundamental cellular functions and assuring its replication and immune system evasion. In particular, the viral 3' Open Reading Frame (ORF3a) codes for a hydrophobic protein, which embeds in the cellular membrane, where it acts as an ion viroporin and is related to strong inflammatory response. Here we report equilibrium and enhanced sampling molecular dynamic simulation of the SARS-CoV-2 ORF3a in a model lipid bilayer, showing how the protein permeabilizes the lipid membrane, via the formation of a water channel, which in turn assures ion transport. We report the free energy profile for both K(+) and Cl(-) transfer from the cytosol to the extracellular domain. The important role of ORF3a in the viral cycle and its high conservation among coronaviruses may also make it a target of choice for future antiviral development, further justifying the elucidation of its mechanism at the atomistic level. Twit Text FOAVip Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome Coronavirus-2 Permeabilization and Polarization of the Host Lipid Membrane by Viroporins ????J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=35593652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35593652 #FOAvip English Wikipedia <ref>{{Cite pmid|35593652}}</ref> Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome Coronavirus-2 Permeabilization and Polarization of the Host Lipid Membrane by Viroporins #MMPMID35593652 Bignon E; Marazzi M; Monari A J Phys Chem Lett 2022[Jun]; 13 (21): 4642-4649 PMID35593652show ga Like all viral infections, SARS-CoV-2 acts at multiple levels, hijacking fundamental cellular functions and assuring its replication and immune system evasion. In particular, the viral 3' Open Reading Frame (ORF3a) codes for a hydrophobic protein, which embeds in the cellular membrane, where it acts as an ion viroporin and is related to strong inflammatory response. Here we report equilibrium and enhanced sampling molecular dynamic simulation of the SARS-CoV-2 ORF3a in a model lipid bilayer, showing how the protein permeabilizes the lipid membrane, via the formation of a water channel, which in turn assures ion transport. We report the free energy profile for both K(+) and Cl(-) transfer from the cytosol to the extracellular domain. The important role of ORF3a in the viral cycle and its high conservation among coronaviruses may also make it a target of choice for future antiviral development, further justifying the elucidation of its mechanism at the atomistic level. |*COVID-19[MESH] |*Cell Membrane/virology[MESH] |*Viroporin Proteins[MESH] |Humans[MESH] |Lipids[MESH]Hijacking of Cellular Functions by Severe Acute Respiratory Syndrome (epmc).pdf DeepDyve Pubget Overpricing