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10.1016/j.ceb.2022.102086 http://scihub22266oqcxt.onion/10.1016/j.ceb.2022.102086 35584589!9108489!35584589     free     free     free       Curr+Opin+Cell+Biol 2022 ; 76 (ä): 102086 Nephropedia Template TP {{tp|p=35584589|t=2022. Roles of PIKfyve in multiple cellular pathways |pdf=|usr=}}{{35584589}} gab.com Text Roles of PIKfyve in multiple cellular pathways JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35584589 #FOAvip Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of cell function. These signaling molecules are difficult to study because they are extremely low abundance. Here, we focus on two of the lowest abundance phosphoinositides, PI(3,5)P(2) and PI(5)P, which play critical roles in cellular homeostasis, membrane trafficking and transcription. Their levels are tightly regulated by a protein complex that includes PIKfyve, Fig4 and Vac14. Importantly, mutations in this complex that decrease PI(3,5)P(2) and PI(5)P are linked to human diseases, especially those of the nervous system. Paradoxically, PIKfyve inhibitors which decrease PI(3,5)P(2) and PI(5)P, are currently being tested for some neurodegenerative diseases, as well as other diverse diseases including some cancers, and as a treatment for SARS-CoV2 infection. A more comprehensive picture of the pathways that are regulated by PIKfyve will be critical to understand the roles of PI(3,5)P(2) and PI(5)P in normal human physiology and in disease. Twit Text FOAVip Roles of PIKfyve in multiple cellular pathways ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35584589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35584589 #FOAvip English Wikipedia <ref>{{Cite pmid|35584589}}</ref> Roles of PIKfyve in multiple cellular pathways #MMPMID35584589 Rivero-Rios P; Weisman LS Curr Opin Cell Biol 2022[Jun]; 76 (ä): 102086 PMID35584589show ga Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of cell function. These signaling molecules are difficult to study because they are extremely low abundance. Here, we focus on two of the lowest abundance phosphoinositides, PI(3,5)P(2) and PI(5)P, which play critical roles in cellular homeostasis, membrane trafficking and transcription. Their levels are tightly regulated by a protein complex that includes PIKfyve, Fig4 and Vac14. Importantly, mutations in this complex that decrease PI(3,5)P(2) and PI(5)P are linked to human diseases, especially those of the nervous system. Paradoxically, PIKfyve inhibitors which decrease PI(3,5)P(2) and PI(5)P, are currently being tested for some neurodegenerative diseases, as well as other diverse diseases including some cancers, and as a treatment for SARS-CoV2 infection. A more comprehensive picture of the pathways that are regulated by PIKfyve will be critical to understand the roles of PI(3,5)P(2) and PI(5)P in normal human physiology and in disease. |*COVID-19 Drug Treatment[MESH] |*Phosphatidylinositol Phosphates/metabolism[MESH] |Flavoproteins/metabolism[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins[MESH] |Membrane Proteins/metabolism[MESH] |Phosphatidylinositol 3-Kinases/metabolism[MESH] |Phosphatidylinositols[MESH] |Phosphoric Monoester Hydrolases[MESH] |RNA, Viral[MESH]Roles of PIKfyve in multiple cellular pathways (epmc).pdf DeepDyve Pubget Overpricing