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10.1016/j.resp.2022.103920 http://scihub22266oqcxt.onion/10.1016/j.resp.2022.103920 35580821!9107181!35580821     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35580821&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Physiol+Neurobiol 2022 ; 303 (ä): 103920 Nephropedia Template TP {{tp|p=35580821|t=2022. Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease |pdf=|usr=}}{{35580821}} gab.com Text Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease JO: Respir Physiol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=35580821 #FOAvip Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to cell is yet an enigma. The present study analyzed the possible role of trypsin in the activation of coronavirus in vitro and in vivo. We found that the overexpression of trypsin in A549 cells upregulated IL-17 and angiotensin-converting enzyme (ACE). In the humanized transgenic mice, trypsin activated M1 macrophages. Together, our results suggested that the upregulation of trypsin may support a new pathway for coronavirus transmission in patients. Twit Text FOAVip Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease ????Respir Physiol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=35580821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35580821 #FOAvip English Wikipedia <ref>{{Cite pmid|35580821}}</ref> Trypsin may induce cytokine storm in M1 macrophages, resulting in critical coronavirus disease #MMPMID35580821 Chen H; Huang S; Chen Q; Liu Q; Lv X Respir Physiol Neurobiol 2022[Sep]; 303 (ä): 103920 PMID35580821show ga Trypsin is a protease-activated receptor-2 (PAR2) activator that upregulates the interleukin (IL)-17 receptor signal in the airway epithelial cells and amplifies the inflammatory response, but does not modify the growth kinetics of the metapneumovirus. How does the coronavirus spread from cell to cell is yet an enigma. The present study analyzed the possible role of trypsin in the activation of coronavirus in vitro and in vivo. We found that the overexpression of trypsin in A549 cells upregulated IL-17 and angiotensin-converting enzyme (ACE). In the humanized transgenic mice, trypsin activated M1 macrophages. Together, our results suggested that the upregulation of trypsin may support a new pathway for coronavirus transmission in patients. |*Cytokine Release Syndrome[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Epithelial Cells/metabolism[MESH] |Humans[MESH] |Macrophages/metabolism[MESH] |Mice[MESH]Trypsin may induce cytokine storm in M1 macrophages, resulting in crit(epmc).pdf DeepDyve Pubget Overpricing