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10.1038/s41419-022-04861-2 http://scihub22266oqcxt.onion/10.1038/s41419-022-04861-2 35568706!9106988!35568706     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2022 ; 13 (5): 461 Nephropedia Template TP {{tp|p=35568706|t=2022. Sex differences in global metabolomic profiles of COVID-19 patients |pdf=|usr=}}{{35568706}} gab.com Text Sex differences in global metabolomic profiles of COVID-19 patients JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=35568706 #FOAvip Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Unsupervised statistical analysis showed a profound sexual dimorphism in correlations between patient-specific clinical parameters and their global metabolic profiles. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients. Twit Text FOAVip Sex differences in global metabolomic profiles of COVID-19 patients ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=35568706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35568706 #FOAvip English Wikipedia <ref>{{Cite pmid|35568706}}</ref> Sex differences in global metabolomic profiles of COVID-19 patients #MMPMID35568706 Escarcega RD; Honarpisheh P; Colpo GD; Ahnstedt HW; Couture L; Juneja S; Torres G; Ortiz GJ; Sollome J; Tabor N; Ganesh BP; Choi HA; Liu F; McCullough LD; Tsvetkov AS Cell Death Dis 2022[May]; 13 (5): 461 PMID35568706show ga Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Unsupervised statistical analysis showed a profound sexual dimorphism in correlations between patient-specific clinical parameters and their global metabolic profiles. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Biomarkers[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolomics[MESH]Sex differences in global metabolomic profiles of COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing