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10.3390/ijms23095283 http://scihub22266oqcxt.onion/10.3390/ijms23095283 35563673!9101079!35563673     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2022 ; 23 (9): ä Nephropedia Template TP {{tp|p=35563673|t=2022. The Role of Nuclear Factor Kappa B (NF-kappaB) in Development and Treatment of COVID-19: Review |pdf=|usr=}}{{35563673}} gab.com Text The Role of Nuclear Factor Kappa B (NF-kappaB) in Development and Treatment of COVID-19: Review JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35563673 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 19 (COVID-19), a disease that has affected more than 500 million people worldwide since the end of 2019. Due to its high complications and death rates, there is still a need to find the best therapy for SARS-CoV-2 infection. The dysregulation of the inflammatory response in COVID-19 plays a very important role in disease progression. It has been observed that abnormal activity of Nuclear Factor kappa B (NF-kappaB) is directly associated with, inter alia, increased synthesis of proinflammatory factors. Therefore, this review paper focuses on the functions of NF-kappaB in the development of SARS-CoV-2 infection and potential application of NF-kappaB inhibitors in COVID-19 immunotherapy. A comprehensive literature search was performed using the MEDLINE/PubMed database. In the current review, it is highlighted that NF-kappaB plays important functions in the modulation of an adaptive inflammatory response, including inducing the expression of proinflammatory genes. Increased activation of NF-kappaB in SARS-CoV-2 infection was observed. The association between NF-kappaB activation and the expression of SARS-CoV-2 structural and non-structural proteins were also reported. It was observed that modulation of NF-kappaB using, e.g., traditional Chinese medicine or glucocorticosteroids resulted in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection. This review summarizes the role of NF-kappaB in COVID-19 and describes its potential immunotherapeutic target in treatment of SARS-CoV-2 infection. However, indisputably more studies involving patients with a severe course of COVID-19 are sorely needed. Twit Text FOAVip The Role of Nuclear Factor Kappa B (NF-kappaB) in Development and Treatment of COVID-19: Review ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35563673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35563673 #FOAvip English Wikipedia <ref>{{Cite pmid|35563673}}</ref> The Role of Nuclear Factor Kappa B (NF-kappaB) in Development and Treatment of COVID-19: Review #MMPMID35563673 Gudowska-Sawczuk M; Mroczko B Int J Mol Sci 2022[May]; 23 (9): ä PMID35563673show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 19 (COVID-19), a disease that has affected more than 500 million people worldwide since the end of 2019. Due to its high complications and death rates, there is still a need to find the best therapy for SARS-CoV-2 infection. The dysregulation of the inflammatory response in COVID-19 plays a very important role in disease progression. It has been observed that abnormal activity of Nuclear Factor kappa B (NF-kappaB) is directly associated with, inter alia, increased synthesis of proinflammatory factors. Therefore, this review paper focuses on the functions of NF-kappaB in the development of SARS-CoV-2 infection and potential application of NF-kappaB inhibitors in COVID-19 immunotherapy. A comprehensive literature search was performed using the MEDLINE/PubMed database. In the current review, it is highlighted that NF-kappaB plays important functions in the modulation of an adaptive inflammatory response, including inducing the expression of proinflammatory genes. Increased activation of NF-kappaB in SARS-CoV-2 infection was observed. The association between NF-kappaB activation and the expression of SARS-CoV-2 structural and non-structural proteins were also reported. It was observed that modulation of NF-kappaB using, e.g., traditional Chinese medicine or glucocorticosteroids resulted in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection. This review summarizes the role of NF-kappaB in COVID-19 and describes its potential immunotherapeutic target in treatment of SARS-CoV-2 infection. However, indisputably more studies involving patients with a severe course of COVID-19 are sorely needed. |COVID-19 Drug Treatment[MESH] |COVID-19/immunology/*pathology[MESH] |Humans[MESH] |Inflammation/pathology[MESH] |NF-kappa B/*metabolism[MESH]The Role of Nuclear Factor Kappa B (NF-kappaB) in Development and Trea(epmc).pdf DeepDyve Pubget Overpricing