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10.21203/rs.3.rs-1576788/v1 http://scihub22266oqcxt.onion/10.21203/rs.3.rs-1576788/v1 35547851!9094105!35547851     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35547851&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Res+Sq 2022 ; ? (?): ? Nephropedia Template TP {{tp|p=35547851|t=2022. CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates |pdf=|usr=}}{{35547851}} gab.com Text CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates JO: Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=35547851 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades antiviral immunity through the expression of viral proteins that block detection, signaling, interferon (IFN) induction, and IFN-stimulated gene (ISG) expression(1, 2). Weak induction of type I IFNs is associated with a hyperinflammatory response in patients that develop severe COVID-19(3, 4, 5). Here we uncover a role for cellular nucleic acid-binding protein (CNBP) in restricting SARS-CoV-2. Typically, CNBP resides in the cytosol and, in response to RNA sensing pathways, undergoes phosphorylation, nuclear translocation, and IFNbeta enhancer DNA binding to turn on IFNbeta gene transcription. In SARS-CoV-2-infected cells CNBP coordinates IFNbeta gene transcription. In addition, CNBP binds SARS-CoV-2 viral RNA directly. CNBP competes with the nucleocapsid (N) protein and prevents viral RNA and nucleocapsid protein from undergoing liquid-liquid phase separation (LLPS) forming condensates critical for viral replication. Consequently, cells and animals lacking CNBP have higher viral loads and CNBP-deficient mice succumb rapidly to infection. Altogether, these findings identify CNBP as a key antiviral factor for SARS-CoV-2, functioning both as a regulator of antiviral IFN gene expression and a cell intrinsic restriction factor that disrupts LLPS to limit viral replication and spread. Twit Text FOAVip CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates ????Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=35547851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35547851 #FOAvip English Wikipedia <ref>{{Cite pmid|35547851}}</ref> CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates #MMPMID35547851 Fitzgerald K; Chen Y; Lei X; Jiang Z; Humphries F; Mustone N; Ramos I; Mutetwa T; Fernandez-Sesma A Res Sq 2022[May]; ? (?): ? PMID35547851show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades antiviral immunity through the expression of viral proteins that block detection, signaling, interferon (IFN) induction, and IFN-stimulated gene (ISG) expression(1, 2). Weak induction of type I IFNs is associated with a hyperinflammatory response in patients that develop severe COVID-19(3, 4, 5). Here we uncover a role for cellular nucleic acid-binding protein (CNBP) in restricting SARS-CoV-2. Typically, CNBP resides in the cytosol and, in response to RNA sensing pathways, undergoes phosphorylation, nuclear translocation, and IFNbeta enhancer DNA binding to turn on IFNbeta gene transcription. In SARS-CoV-2-infected cells CNBP coordinates IFNbeta gene transcription. In addition, CNBP binds SARS-CoV-2 viral RNA directly. CNBP competes with the nucleocapsid (N) protein and prevents viral RNA and nucleocapsid protein from undergoing liquid-liquid phase separation (LLPS) forming condensates critical for viral replication. Consequently, cells and animals lacking CNBP have higher viral loads and CNBP-deficient mice succumb rapidly to infection. Altogether, these findings identify CNBP as a key antiviral factor for SARS-CoV-2, functioning both as a regulator of antiviral IFN gene expression and a cell intrinsic restriction factor that disrupts LLPS to limit viral replication and spread. ?CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein (epmc).pdf DeepDyve Pubget Overpricing