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10.1182/bloodadvances.2021006944 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2021006944 35543533!9098525!35543533     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Adv 2022 ; 6 (13): 4041-4048 Nephropedia Template TP {{tp|p=35543533|t=2022. Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis |pdf=|usr=}}{{35543533}} gab.com Text Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=35543533 #FOAvip Post-COVID syndrome (PCS), or long COVID, is an increasingly recognized complication of acute SARS-CoV-2 infection, characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness of breath, and cognitive slowing. Acute COVID-19 is strongly linked with an increased risk of thrombosis, which is a prothrombotic state quantified by an elevated von Willebrand factor (VWF) antigen (Ag)/ADAMTS13 ratio that is associated with severity of acute COVID-19 infection. We investigated whether patients with PCS also had evidence of a prothrombotic state associated with symptom severity. In a large cohort of patients referred to a dedicated post-COVID-19 clinic, thrombotic risk, including VWF(Ag)/ADAMTS13 ratio, was investigated. An elevated VWF(Ag)/ADAMTS13 ratio (>/=1.5) was present in nearly one-third of the cohort and was 4 times more likely to be present in patients with impaired exercise capacity, as evidenced by desaturation >/=3% and/or an increase in lactate level >1 from baseline on a 1-minute sit-to-stand test and/or a 6-minute walk test (P < .0001). Of 276 patients, 56 (20%) had impaired exercise capacity, of which 55% (31/56) had a VWF(Ag)/ADAMTS13 ratio >/=1.5 (P < .0001). Factor VIII and VWF(Ag) were elevated in 26% and 18%, respectively, and support a hypercoagulable state in some patients with PCS. These findings suggest possible ongoing microvascular/endothelial dysfunction in the pathogenesis of PCS and suggest a role for antithrombotic therapy in the treatment of these patients. Twit Text FOAVip Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=35543533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35543533 #FOAvip English Wikipedia <ref>{{Cite pmid|35543533}}</ref> Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis #MMPMID35543533 Prasannan N; Heightman M; Hillman T; Wall E; Bell R; Kessler A; Neave L; Doyle A; Devaraj A; Singh D; Dehbi HM; Scully M Blood Adv 2022[Jul]; 6 (13): 4041-4048 PMID35543533show ga Post-COVID syndrome (PCS), or long COVID, is an increasingly recognized complication of acute SARS-CoV-2 infection, characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness of breath, and cognitive slowing. Acute COVID-19 is strongly linked with an increased risk of thrombosis, which is a prothrombotic state quantified by an elevated von Willebrand factor (VWF) antigen (Ag)/ADAMTS13 ratio that is associated with severity of acute COVID-19 infection. We investigated whether patients with PCS also had evidence of a prothrombotic state associated with symptom severity. In a large cohort of patients referred to a dedicated post-COVID-19 clinic, thrombotic risk, including VWF(Ag)/ADAMTS13 ratio, was investigated. An elevated VWF(Ag)/ADAMTS13 ratio (>/=1.5) was present in nearly one-third of the cohort and was 4 times more likely to be present in patients with impaired exercise capacity, as evidenced by desaturation >/=3% and/or an increase in lactate level >1 from baseline on a 1-minute sit-to-stand test and/or a 6-minute walk test (P < .0001). Of 276 patients, 56 (20%) had impaired exercise capacity, of which 55% (31/56) had a VWF(Ag)/ADAMTS13 ratio >/=1.5 (P < .0001). Factor VIII and VWF(Ag) were elevated in 26% and 18%, respectively, and support a hypercoagulable state in some patients with PCS. These findings suggest possible ongoing microvascular/endothelial dysfunction in the pathogenesis of PCS and suggest a role for antithrombotic therapy in the treatment of these patients. |*COVID-19/complications[MESH] |*Thrombosis[MESH] |ADAM Proteins[MESH] |ADAMTS13 Protein[MESH] |Exercise Tolerance[MESH] |Humans[MESH] |Post-Acute COVID-19 Syndrome[MESH] |SARS-CoV-2[MESH]Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-(epmc).pdf DeepDyve Pubget Overpricing