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10.1038/s41398-022-01948-4

http://scihub22266oqcxt.onion/10.1038/s41398-022-01948-4
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35538069!9086665!35538069
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suck abstract from ncbi


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pmid35538069      Transl+Psychiatry 2022 ; 12 (1): 193
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  • Shared genomic architectures of COVID-19 and antisocial behavior #MMPMID35538069
  • Adams CD; Tielbeek JJ; Boutwell BB
  • Transl Psychiatry 2022[May]; 12 (1): 193 PMID35538069show ga
  • Little is known about the genetics of norm violation and aggression in relation to coronavirus disease 2019 (COVID-19). To investigate this, we used summary statistics from genome-wide association studies and linkage disequilibrium score regression to calculate a matrix of genetic correlations (r(gs)) for antisocial behavior (ASB), COVID-19, and various health and behavioral traits. After false-discovery rate correction, ASB was genetically correlated with COVID-19 (r(g) = 0.51; P = 1.54E-02) and 19 other traits. ASB and COVID-19 were both positively genetically correlated with having a noisy workplace, doing heavy manual labor, chronic obstructive pulmonary disease, and genitourinary diseases. ASB and COVID-19 were both inversely genetically correlated with average income, education years, healthspan, verbal reasoning, lifespan, cheese intake, and being breastfed as a baby. But keep in mind that r(gs) are not necessarily causal. And, if causal, their prevailing directions of effect (which causes which) are indiscernible from r(gs) alone. Moreover, the SNP-heritability ([Formula: see text]) estimates for two measures of COVID-19 were very small, restricting the overlap of genetic variance in absolute terms between ASB and COVID-19. Nonetheless, our findings suggest that those with antisocial tendencies possibly have a higher risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those without antisocial tendencies. This may have been especially true early in the pandemic before vaccines against SARS-CoV-2 were available and before the emergence of the highly transmissible Omicron variant.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2/genetics[MESH]
  • |Antisocial Personality Disorder/genetics[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Genomics[MESH]


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