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10.1007/s00018-022-04290-6 http://scihub22266oqcxt.onion/10.1007/s00018-022-04290-6 35536484!9087173!35536484     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2022 ; 79 (6): 288 Nephropedia Template TP {{tp|p=35536484|t=2022. Intracellular mono-ADP-ribosyltransferases at the host-virus interphase |pdf=|usr=}}{{35536484}} gab.com Text Intracellular mono-ADP-ribosyltransferases at the host-virus interphase JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35536484 #FOAvip The innate immune system, the primary defense mechanism of higher organisms against pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In response to PAMPs, interferons (IFNs) are produced, allowing the host to react swiftly to viral infection. In turn the expression of IFN-stimulated genes (ISGs) is induced. Their products disseminate the antiviral response. Among the ISGs conserved in many species are those encoding mono-ADP-ribosyltransferases (mono-ARTs). This prompts the question whether, and if so how, mono-ADP-ribosylation affects viral propagation. Emerging evidence demonstrates that some mono-ADP-ribosyltransferases function as PAMP receptors and modify both host and viral proteins relevant for viral replication. Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. We summarize and discuss the evidence linking mono-ADP-ribosylation and the enzymes relevant to catalyze this reversible modification with the innate immune response as part of the arms race between host and viruses. Twit Text FOAVip Intracellular mono-ADP-ribosyltransferases at the host-virus interphase ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35536484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35536484 #FOAvip English Wikipedia <ref>{{Cite pmid|35536484}}</ref> Intracellular mono-ADP-ribosyltransferases at the host-virus interphase #MMPMID35536484 Luscher B; Verheirstraeten M; Krieg S; Korn P Cell Mol Life Sci 2022[May]; 79 (6): 288 PMID35536484show ga The innate immune system, the primary defense mechanism of higher organisms against pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In response to PAMPs, interferons (IFNs) are produced, allowing the host to react swiftly to viral infection. In turn the expression of IFN-stimulated genes (ISGs) is induced. Their products disseminate the antiviral response. Among the ISGs conserved in many species are those encoding mono-ADP-ribosyltransferases (mono-ARTs). This prompts the question whether, and if so how, mono-ADP-ribosylation affects viral propagation. Emerging evidence demonstrates that some mono-ADP-ribosyltransferases function as PAMP receptors and modify both host and viral proteins relevant for viral replication. Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. We summarize and discuss the evidence linking mono-ADP-ribosylation and the enzymes relevant to catalyze this reversible modification with the innate immune response as part of the arms race between host and viruses. |*ADP Ribose Transferases[MESH] |*Viruses[MESH] |Interphase[MESH] |Pathogen-Associated Molecular Pattern Molecules[MESH]Intracellular mono-ADP-ribosyltransferases at the host-virus interphas(epmc).pdf DeepDyve Pubget Overpricing