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pmid3553482      J+Hypertens+Suppl 1986 ; 4 (5): S515-8
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  • Amiloride with or without salbutamol versus placebo: effects on lipoproteins in hypertensive patients treated with timolol-hydrochlorothiazide #MMPMID3553482
  • Spence JD; Wong DG
  • J Hypertens Suppl 1986[Dec]; 4 (5): S515-8 PMID3553482show ga
  • Because thiazides and beta-blockers have adverse effects on lipoproteins, while magnesium repletion (shown to occur with amiloride) and beta 2 agonists improve lipids, we studied the effects of 3 months each of amiloride with and without salbutamol with and without placebo in a 2 X 2 factorial crossover study in which all patients took timolol-hydrochlorothiazide twice daily for 1 year. A total of 118 subjects entered, and 97 patients completed all four crossovers of amiloride + salbutamol, amiloride + placebo, salbutamol + placebo and placebo + placebo. No significant differences were seen among the four study regimens with respect to blood pressure, total cholesterol, triglycerides or high-density lipoproteins (HDL). The study power was 99% for total cholesterol, 46% for triglycerides and 93% for HDL. Timolol-hydrochlorothiazide had no significant effect, suggesting that the use of such drugs to offset the adverse effects of antihypertensive drugs on lipoproteins is not effective; the selection of alternative antihypertensive agents appears to be a preferable strategy.
  • |Albuterol/*administration & dosage/therapeutic use[MESH]
  • |Amiloride/*administration & dosage/therapeutic use[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Humans[MESH]
  • |Hydrochlorothiazide/*adverse effects/therapeutic use[MESH]
  • |Hypertension/*drug therapy[MESH]
  • |Lipoproteins/*blood[MESH]


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