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10.1038/s42255-022-00567-z http://scihub22266oqcxt.onion/10.1038/s42255-022-00567-z 35534727!ä!35534727 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Metab 2022 ; 4 (5): 547-558 Nephropedia Template TP {{tp|p=35534727|t=2022. A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 |pdf=|usr=}}{{35534727}} gab.com Text A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 JO: Nat Metab http://www.kidney.de/pget.php?&tw=1&pmid=35534727 #FOAvip The severity and mortality of COVID-19 are associated with pre-existing medical comorbidities such as diabetes mellitus. However, the underlying causes for increased susceptibility to viral infection in patients with diabetes is not fully understood. Here we identify several small-molecule metabolites from human blood with effective antiviral activity against SARS-CoV-2, one of which, 1,5-anhydro-D-glucitol (1,5-AG), is associated with diabetes mellitus. The serum 1,5-AG level is significantly lower in patients with diabetes. In vitro, the level of SARS-CoV-2 replication is higher in the presence of serum from patients with diabetes than from healthy individuals and this is counteracted by supplementation of 1,5-AG to the serum from patients. Diabetic (db/db) mice undergo SARS-CoV-2 infection accompanied by much higher viral loads and more severe respiratory tissue damage when compared to wild-type mice. Sustained supplementation of 1,5-AG in diabetic mice reduces SARS-CoV-2 loads and disease severity to similar levels in nondiabetic mice. Mechanistically, 1,5-AG directly binds the S2 subunit of the SARS-CoV-2 spike protein, thereby interrupting spike-mediated virus-host membrane fusion. Our results reveal a mechanism that contributes to COVID-19 pathogenesis in the diabetic population and suggest that 1,5-AG supplementation may be beneficial to diabetic patients against severe COVID-19. Twit Text FOAVip A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 ????Nat Metab http://www.kidney.de/pget.php?&tw=1&pmid=35534727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35534727 #FOAvip English Wikipedia <ref>{{Cite pmid|35534727}}</ref> A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 #MMPMID35534727 Tong L; Xiao X; Li M; Fang S; Ma E; Yu X; Zhu Y; Wu C; Tian D; Yang F; Sun J; Qu J; Zheng N; Liao S; Tai W; Feng S; Zhang L; Li Y; Wang L; Han X; Sun S; Yang L; Zhong H; Zhao J; Liu W; Liu X; Wang P; Li L; Zhao G; Zhang R; Cheng G Nat Metab 2022[May]; 4 (5): 547-558 PMID35534727show ga The severity and mortality of COVID-19 are associated with pre-existing medical comorbidities such as diabetes mellitus. However, the underlying causes for increased susceptibility to viral infection in patients with diabetes is not fully understood. Here we identify several small-molecule metabolites from human blood with effective antiviral activity against SARS-CoV-2, one of which, 1,5-anhydro-D-glucitol (1,5-AG), is associated with diabetes mellitus. The serum 1,5-AG level is significantly lower in patients with diabetes. In vitro, the level of SARS-CoV-2 replication is higher in the presence of serum from patients with diabetes than from healthy individuals and this is counteracted by supplementation of 1,5-AG to the serum from patients. Diabetic (db/db) mice undergo SARS-CoV-2 infection accompanied by much higher viral loads and more severe respiratory tissue damage when compared to wild-type mice. Sustained supplementation of 1,5-AG in diabetic mice reduces SARS-CoV-2 loads and disease severity to similar levels in nondiabetic mice. Mechanistically, 1,5-AG directly binds the S2 subunit of the SARS-CoV-2 spike protein, thereby interrupting spike-mediated virus-host membrane fusion. Our results reveal a mechanism that contributes to COVID-19 pathogenesis in the diabetic population and suggest that 1,5-AG supplementation may be beneficial to diabetic patients against severe COVID-19. |*COVID-19[MESH] |*Diabetes Mellitus, Experimental[MESH] |Animals[MESH] |Glucose[MESH] |Humans[MESH] |Mice[MESH] |SARS-CoV-2[MESH]A glucose-like metabolite deficient in diabetes inhibits cellular entr(epmc).pdf DeepDyve Pubget Overpricing