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10.1101/cshperspect.a041157

http://scihub22266oqcxt.onion/10.1101/cshperspect.a041157
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35534210!9524390!35534210
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suck abstract from ncbi


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pmid35534210      Cold+Spring+Harb+Perspect+Med 2022 ; 12 (10): ä
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  • Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19 #MMPMID35534210
  • Mentzer SJ; Ackermann M; Jonigk D
  • Cold Spring Harb Perspect Med 2022[Oct]; 12 (10): ä PMID35534210show ga
  • COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying autopsy patients succumbing to COVID-19, we found alveolar capillary microthrombi were 9 times more common in COVID-19 than in comparable patients with influenza. Corrosion casting of the COVID-19 microcirculation has revealed microvascular distortion, enhanced bronchial circulation, and striking increases in intussusceptive angiogenesis. In patients with severe COVID-19, endothelial cells commonly demonstrate significant ultrastructural injury. High-resolution imaging suggests that microcirculation perturbations are linked to ischemic changes in microanatomic compartments of the lung (secondary lobules). NanoString profiling of these regions has confirmed a transcriptional signature compatible with microischemia. We conclude that irreversible tissue ischemia provides an explanation for the cystic and fibrotic changes associated with long-haul COVID-19 symptoms.
  • |*COVID-19/complications/pathology/physiopathology[MESH]
  • |*Endothelial Cells/pathology/ultrastructure[MESH]
  • |*Ischemia/complications[MESH]
  • |*Microcirculation[MESH]
  • |*Neovascularization, Pathologic/complications[MESH]
  • |Corrosion Casting[MESH]
  • |Humans[MESH]


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