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10.1101/cshperspect.a041157 http://scihub22266oqcxt.onion/10.1101/cshperspect.a041157 35534210!9524390!35534210     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35534210.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Med 2022 ; 12 (10): ä Nephropedia Template TP {{tp|p=35534210|t=2022. Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19 |pdf=|usr=}}{{35534210}} gab.com Text Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19 JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=35534210 #FOAvip COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying autopsy patients succumbing to COVID-19, we found alveolar capillary microthrombi were 9 times more common in COVID-19 than in comparable patients with influenza. Corrosion casting of the COVID-19 microcirculation has revealed microvascular distortion, enhanced bronchial circulation, and striking increases in intussusceptive angiogenesis. In patients with severe COVID-19, endothelial cells commonly demonstrate significant ultrastructural injury. High-resolution imaging suggests that microcirculation perturbations are linked to ischemic changes in microanatomic compartments of the lung (secondary lobules). NanoString profiling of these regions has confirmed a transcriptional signature compatible with microischemia. We conclude that irreversible tissue ischemia provides an explanation for the cystic and fibrotic changes associated with long-haul COVID-19 symptoms. Twit Text FOAVip Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19 ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=35534210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35534210 #FOAvip English Wikipedia <ref>{{Cite pmid|35534210}}</ref> Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19 #MMPMID35534210 Mentzer SJ; Ackermann M; Jonigk D Cold Spring Harb Perspect Med 2022[Oct]; 12 (10): ä PMID35534210show ga COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying autopsy patients succumbing to COVID-19, we found alveolar capillary microthrombi were 9 times more common in COVID-19 than in comparable patients with influenza. Corrosion casting of the COVID-19 microcirculation has revealed microvascular distortion, enhanced bronchial circulation, and striking increases in intussusceptive angiogenesis. In patients with severe COVID-19, endothelial cells commonly demonstrate significant ultrastructural injury. High-resolution imaging suggests that microcirculation perturbations are linked to ischemic changes in microanatomic compartments of the lung (secondary lobules). NanoString profiling of these regions has confirmed a transcriptional signature compatible with microischemia. We conclude that irreversible tissue ischemia provides an explanation for the cystic and fibrotic changes associated with long-haul COVID-19 symptoms. |*COVID-19/complications/pathology/physiopathology[MESH] |*Endothelial Cells/pathology/ultrastructure[MESH] |*Ischemia/complications[MESH] |*Microcirculation[MESH] |*Neovascularization, Pathologic/complications[MESH] |Corrosion Casting[MESH] |Humans[MESH]Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in CO(epmc).pdf DeepDyve Pubget Overpricing