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10.1016/j.jacbts.2022.01.013 http://scihub22266oqcxt.onion/10.1016/j.jacbts.2022.01.013 35530264!9067411!35530264     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JACC+Basic+Transl+Sci 2022 ; 7 (5): 425-441 Nephropedia Template TP {{tp|p=35530264|t=2022. Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics |pdf=|usr=}}{{35530264}} gab.com Text Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics JO: JACC Basic Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=35530264 #FOAvip To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFbeta signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications. Twit Text FOAVip Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics ????JACC Basic Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=35530264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35530264 #FOAvip English Wikipedia <ref>{{Cite pmid|35530264}}</ref> Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics #MMPMID35530264 Roh JD; Kitchen RR; Guseh JS; McNeill JN; Aid M; Martinot AJ; Yu A; Platt C; Rhee J; Weber B; Trager LE; Hastings MH; Ducat S; Xia P; Castro C; Singh A; Atlason B; Churchill TW; Di Carli MF; Ellinor PT; Barouch DH; Ho JE; Rosenzweig A JACC Basic Transl Sci 2022[May]; 7 (5): 425-441 PMID35530264show ga To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFbeta signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications. äPlasma Proteomics of COVID-19-Associated Cardiovascular Complications:(epmc).pdf DeepDyve Pubget Overpricing