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10.1155/2022/6089242 http://scihub22266oqcxt.onion/10.1155/2022/6089242 35528178!9073549!35528178     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2022 ; 2022 (ä): 6089242 Nephropedia Template TP {{tp|p=35528178|t=2022. Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods |pdf=|usr=}}{{35528178}} gab.com Text Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=35528178 #FOAvip COVID-19 is hypothesized to be linked to the host's excessive inflammatory immunological response to SARS-CoV-2 infection, which is regarded to be a major factor in disease severity and mortality. Numerous immune cells play a key role in immune response regulation, and gene expression analysis in these cells could be a useful method for studying disease states, assessing immunological responses, and detecting biomarkers. Here, we developed a machine learning procedure to find biomarkers that discriminate disease severity in individual immune cells (B cell, CD4(+) cell, CD8(+) cell, monocyte, and NK cell) using single-cell gene expression profiles of COVID-19. The gene features of each profile were first filtered and ranked using the Boruta feature selection method and mRMR, and the resulting ranked feature lists were then fed into the incremental feature selection method to determine the optimal number of features with decision tree and random forest algorithms. Meanwhile, we extracted the classification rules in each cell type from the optimal decision tree classifiers. The best gene sets discovered in this study were analyzed by GO and KEGG pathway enrichment, and some important biomarkers like TLR2, ITK, CX3CR1, IL1B, and PRDM1 were validated by recent literature. The findings reveal that the optimal gene sets for each cell type can accurately classify COVID-19 disease severity and provide insight into the molecular mechanisms involved in disease progression. Twit Text FOAVip Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=35528178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35528178 #FOAvip English Wikipedia <ref>{{Cite pmid|35528178}}</ref> Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods #MMPMID35528178 Chen L; Mei Z; Guo W; Ding S; Huang T; Cai YD Biomed Res Int 2022[]; 2022 (ä): 6089242 PMID35528178show ga COVID-19 is hypothesized to be linked to the host's excessive inflammatory immunological response to SARS-CoV-2 infection, which is regarded to be a major factor in disease severity and mortality. Numerous immune cells play a key role in immune response regulation, and gene expression analysis in these cells could be a useful method for studying disease states, assessing immunological responses, and detecting biomarkers. Here, we developed a machine learning procedure to find biomarkers that discriminate disease severity in individual immune cells (B cell, CD4(+) cell, CD8(+) cell, monocyte, and NK cell) using single-cell gene expression profiles of COVID-19. The gene features of each profile were first filtered and ranked using the Boruta feature selection method and mRMR, and the resulting ranked feature lists were then fed into the incremental feature selection method to determine the optimal number of features with decision tree and random forest algorithms. Meanwhile, we extracted the classification rules in each cell type from the optimal decision tree classifiers. The best gene sets discovered in this study were analyzed by GO and KEGG pathway enrichment, and some important biomarkers like TLR2, ITK, CX3CR1, IL1B, and PRDM1 were validated by recent literature. The findings reveal that the optimal gene sets for each cell type can accurately classify COVID-19 disease severity and provide insight into the molecular mechanisms involved in disease progression. |*COVID-19/genetics[MESH] |Algorithms[MESH] |Biomarkers[MESH] |Humans[MESH] |Machine Learning[MESH]Recognition of Immune Cell Markers of COVID-19 Severity with Machine L(epmc).pdf DeepDyve Pubget Overpricing