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10.15252/embr.202154305 http://scihub22266oqcxt.onion/10.15252/embr.202154305 35527514!9171409!35527514     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2022 ; 23 (6): e54305 Nephropedia Template TP {{tp|p=35527514|t=2022. ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion |pdf=|usr=}}{{35527514}} gab.com Text ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=35527514 #FOAvip The severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19, but host cell factors contributing to COVID-19 pathogenesis remain only partly understood. We identify the host metalloprotease ADAM17 as a facilitator of SARS-CoV-2 cell entry and the metalloprotease ADAM10 as a host factor required for lung cell syncytia formation, a hallmark of COVID-19 pathology. ADAM10 and ADAM17, which are broadly expressed in the human lung, cleave the SARS-CoV-2 spike protein (S) in vitro, indicating that ADAM10 and ADAM17 contribute to the priming of S, an essential step for viral entry and cell fusion. ADAM protease-targeted inhibitors severely impair lung cell infection by the SARS-CoV-2 variants of concern alpha, beta, delta, and omicron and also reduce SARS-CoV-2 infection of primary human lung cells in a TMPRSS2 protease-independent manner. Our study establishes ADAM10 and ADAM17 as host cell factors for viral entry and syncytia formation and defines both proteases as potential targets for antiviral drug development. Twit Text FOAVip ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=35527514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35527514 #FOAvip English Wikipedia <ref>{{Cite pmid|35527514}}</ref> ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion #MMPMID35527514 Jocher G; Grass V; Tschirner SK; Riepler L; Breimann S; Kaya T; Oelsner M; Hamad MS; Hofmann LI; Blobel CP; Schmidt-Weber CB; Gokce O; Jakwerth CA; Trimpert J; Kimpel J; Pichlmair A; Lichtenthaler SF EMBO Rep 2022[Jun]; 23 (6): e54305 PMID35527514show ga The severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19, but host cell factors contributing to COVID-19 pathogenesis remain only partly understood. We identify the host metalloprotease ADAM17 as a facilitator of SARS-CoV-2 cell entry and the metalloprotease ADAM10 as a host factor required for lung cell syncytia formation, a hallmark of COVID-19 pathology. ADAM10 and ADAM17, which are broadly expressed in the human lung, cleave the SARS-CoV-2 spike protein (S) in vitro, indicating that ADAM10 and ADAM17 contribute to the priming of S, an essential step for viral entry and cell fusion. ADAM protease-targeted inhibitors severely impair lung cell infection by the SARS-CoV-2 variants of concern alpha, beta, delta, and omicron and also reduce SARS-CoV-2 infection of primary human lung cells in a TMPRSS2 protease-independent manner. Our study establishes ADAM10 and ADAM17 as host cell factors for viral entry and syncytia formation and defines both proteases as potential targets for antiviral drug development. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |ADAM10 Protein/genetics[MESH] |ADAM17 Protein[MESH] |Amyloid Precursor Protein Secretases/genetics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Cell Fusion[MESH] |Humans[MESH] |Lung[MESH] |Membrane Proteins/genetics/metabolism[MESH] |Metalloproteases[MESH] |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH]ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-medi(epmc).pdf DeepDyve Pubget Overpricing