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Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals #MMPMID35513399
Horve PF; Dietz LG; Bowles G; MacCrone G; Olsen-Martinez A; Northcutt D; Moore V; Barnatan L; Parhizkar H; Van Den Wymelenberg KG
Sci Rep 2022[May]; 12 (1): 7395 PMID35513399show ga
The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the air and increased connectivity between the individuals occupying indoor spaces. In this study, we aimed to track a cohort of subjects as they occupied a COVID-19 isolation dormitory to better understand the impact of subject and environmental viral load over time, symptoms, and room ventilation on the detectable viral load within a single room. We find that subject samples demonstrate a decrease in overall viral load over time, symptoms significantly impact environmental viral load, and we provide the first real-world evidence for decreased aerosol SARS-CoV-2 load with increasing ventilation, both from mechanical and window sources. These results may guide environmental viral surveillance strategies and be used to better control the spread of SARS-CoV-2 within built environments and better protect those caring for individuals with COVID-19.