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10.1371/journal.ppat.1010471 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1010471 35512020!9113601!35512020     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35512020.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2022 ; 18 (5): e1010471 Nephropedia Template TP {{tp|p=35512020|t=2022. Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection |pdf=|usr=}}{{35512020}} gab.com Text Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35512020 #FOAvip The ability to treat severe viral infections is limited by our understanding of the mechanisms behind virus-induced immunopathology. While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known about how IFNs can regulate the development of immunopathology and affect disease outcomes. Here, we report that absence of type I IFN receptor (IFNAR) is associated with extensive immunopathology following mucosal viral infection. This pathology occurred independent of viral load or type II immunity but required the presence of macrophages and IL-6. The depletion of macrophages and inhibition of IL-6 signaling significantly abrogated immunopathology. Tissue destruction was mediated by macrophage-derived matrix metalloproteinases (MMPs), as MMP inhibition by doxycycline and Ro 28-2653 reduced the severity of tissue pathology. Analysis of post-mortem COVID-19 patient lungs also displayed significant upregulation of the expression of MMPs and accumulation of macrophages. Overall, we demonstrate that IFNs inhibit macrophage-mediated MMP production to prevent virus-induced immunopathology and uncover MMPs as a therapeutic target towards viral infections. Twit Text FOAVip Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=35512020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35512020 #FOAvip English Wikipedia <ref>{{Cite pmid|35512020}}</ref> Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection #MMPMID35512020 Lee AJ; Feng E; Chew MV; Balint E; Poznanski SM; Giles E; Zhang A; Marzok A; Revill SD; Vahedi F; Dubey A; Ayaub E; Jimenez-Saiz R; McGrath JJC; Ritchie TM; Jordana M; Jonigk DD; Ackermann M; Ask K; Miller M; Richards CD; Ashkar AA PLoS Pathog 2022[May]; 18 (5): e1010471 PMID35512020show ga The ability to treat severe viral infections is limited by our understanding of the mechanisms behind virus-induced immunopathology. While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known about how IFNs can regulate the development of immunopathology and affect disease outcomes. Here, we report that absence of type I IFN receptor (IFNAR) is associated with extensive immunopathology following mucosal viral infection. This pathology occurred independent of viral load or type II immunity but required the presence of macrophages and IL-6. The depletion of macrophages and inhibition of IL-6 signaling significantly abrogated immunopathology. Tissue destruction was mediated by macrophage-derived matrix metalloproteinases (MMPs), as MMP inhibition by doxycycline and Ro 28-2653 reduced the severity of tissue pathology. Analysis of post-mortem COVID-19 patient lungs also displayed significant upregulation of the expression of MMPs and accumulation of macrophages. Overall, we demonstrate that IFNs inhibit macrophage-mediated MMP production to prevent virus-induced immunopathology and uncover MMPs as a therapeutic target towards viral infections. |*COVID-19[MESH] |*Interferon Type I[MESH] |*Orthomyxoviridae Infections[MESH] |Humans[MESH] |Interleukin-6/metabolism[MESH] |Macrophages/metabolism[MESH]Type I interferon regulates proteolysis by macrophages to prevent immu(epmc).pdf DeepDyve Pubget Overpricing