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10.1007/s11427-021-2099-7 http://scihub22266oqcxt.onion/10.1007/s11427-021-2099-7 35508791!9068507!35508791     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+China+Life+Sci 2022 ; 65 (10): 1971-1984 Nephropedia Template TP {{tp|p=35508791|t=2022. Identification of serum metabolites enhancing inflammatory responses in COVID-19 |pdf=|usr=}}{{35508791}} gab.com Text Identification of serum metabolites enhancing inflammatory responses in COVID-19 JO: Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35508791 #FOAvip Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a strong production of inflammatory cytokines such as TNF and IL-6, which underlie the severity of the disease. However, the molecular mechanisms responsible for such a strong immune response remains unclear. Here, utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages, we identified that 611 metabolites (of 1,039) were significantly altered in COVID-19 patients. Among them, two metabolites, agmatine and putrescine, were prominently elevated in the serum of patients; and 2-quinolinecarboxylate was changed in a biphasic manner, elevated during early COVID-19 infection but levelled off. When tested in mouse embryonic fibroblasts (MEFs) and macrophages, these 3 metabolites were found to activate the NF-kappaB pathway that plays a pivotal role in governing cytokine production. Importantly, these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice, but not in the mice lacking NF-kappaB. Intriguingly, these metabolites have little effects on the activation of interferon regulatory factors (IRFs) for the production of type I interferons (IFNs) for antiviral defenses. These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses, exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons. Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients. Twit Text FOAVip Identification of serum metabolites enhancing inflammatory responses in COVID-19 ????Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35508791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35508791 #FOAvip English Wikipedia <ref>{{Cite pmid|35508791}}</ref> Identification of serum metabolites enhancing inflammatory responses in COVID-19 #MMPMID35508791 Zhang CS; Zhang B; Li M; Wei X; Gong K; Li Z; Yao X; Wu J; Zhang C; Zhu M; Zhang L; Sun X; Zhan YH; Jiang Z; Zhao W; Zhong W; Zhuang X; Zhou D; Piao HL; Lin SC; Wang Z Sci China Life Sci 2022[Oct]; 65 (10): 1971-1984 PMID35508791show ga Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a strong production of inflammatory cytokines such as TNF and IL-6, which underlie the severity of the disease. However, the molecular mechanisms responsible for such a strong immune response remains unclear. Here, utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages, we identified that 611 metabolites (of 1,039) were significantly altered in COVID-19 patients. Among them, two metabolites, agmatine and putrescine, were prominently elevated in the serum of patients; and 2-quinolinecarboxylate was changed in a biphasic manner, elevated during early COVID-19 infection but levelled off. When tested in mouse embryonic fibroblasts (MEFs) and macrophages, these 3 metabolites were found to activate the NF-kappaB pathway that plays a pivotal role in governing cytokine production. Importantly, these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice, but not in the mice lacking NF-kappaB. Intriguingly, these metabolites have little effects on the activation of interferon regulatory factors (IRFs) for the production of type I interferons (IFNs) for antiviral defenses. These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses, exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons. Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients. |*Agmatine[MESH] |*COVID-19[MESH] |*Interferon Type I/metabolism[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |Cytokines/metabolism[MESH] |Fibroblasts/metabolism[MESH] |Interferon Regulatory Factors/metabolism[MESH] |Interleukin-6/metabolism[MESH] |Mice[MESH] |NF-kappa B/metabolism[MESH] |Putrescine[MESH]Identification of serum metabolites enhancing inflammatory responses i(epmc).pdf DeepDyve Pubget Overpricing