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An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir #MMPMID35496844
Moorthy R; Kennelly SA; Rodriguez DJ; Harki DA
RSC Adv 2021[Sep]; 11 (50): 31373-31376 PMID35496844show ga
Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.