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10.1016/j.clim.2022.109024

http://scihub22266oqcxt.onion/10.1016/j.clim.2022.109024
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35489643!9042722!35489643
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suck abstract from ncbi


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pmid35489643      Clin+Immunol 2022 ; 238 (ä): 109024
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  • Myeloid-derived suppressor cells in COVID-19: A review #MMPMID35489643
  • Perfilyeva YV; Ostapchuk YO; Tleulieva R; Kali A; Abdolla N; Krasnoshtanov VK; Perfilyeva AV; Belyaev NN
  • Clin Immunol 2022[May]; 238 (ä): 109024 PMID35489643show ga
  • Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing number of studies are reporting on the expansion of myeloid cells with immunoregulatory activities in the periphery and airways of COVID-19 patients. These cells share phenotypic and functional similarities with myeloid-derived suppressor cells (MDSCs), which were first described in cancer patients. MDSCs are a heterogeneous population of pathologically activated myeloid cells that exert immunosuppressive activities against mainly effector T cells. The increased frequency of these cells in COVID-19 patients suggests that they are involved in immune regulation during this infection. In this article, we review the current findings on MDSCs in COVID-19 and discuss the complex role of these cells in the immunopathology of COVID-19.
  • |*COVID-19[MESH]
  • |*Myeloid-Derived Suppressor Cells[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |SARS-CoV-2[MESH]


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