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10.1038/s41564-022-01105-z http://scihub22266oqcxt.onion/10.1038/s41564-022-01105-z 35484231!9084242!35484231     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2022 ; 7 (5): 640-652 Nephropedia Template TP {{tp|p=35484231|t=2022. Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness |pdf=|usr=}}{{35484231}} gab.com Text Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35484231 #FOAvip The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly understood. We captured the dynamics of infectious virus and viral RNA shedding during acute infection through daily longitudinal sampling of 60 individuals for up to 14 days. By fitting mechanistic models, we directly estimated viral expansion and clearance rates and overall infectiousness for each individual. Significant person-to-person variation in infectious virus shedding suggests that individual-level heterogeneity in viral dynamics contributes to 'superspreading'. Viral genome loads often peaked days earlier in saliva than in nasal swabs, indicating strong tissue compartmentalization and suggesting that saliva may serve as a superior sampling site for early detection of infection. Viral loads and clearance kinetics of Alpha (B.1.1.7) and previously circulating non-variant-of-concern viruses were mostly indistinguishable, indicating that the enhanced transmissibility of this variant cannot be explained simply by higher viral loads or delayed clearance. These results provide a high-resolution portrait of SARS-CoV-2 infection dynamics and implicate individual-level heterogeneity in infectiousness in superspreading. Twit Text FOAVip Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=35484231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35484231 #FOAvip English Wikipedia <ref>{{Cite pmid|35484231}}</ref> Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness #MMPMID35484231 Ke R; Martinez PP; Smith RL; Gibson LL; Mirza A; Conte M; Gallagher N; Luo CH; Jarrett J; Zhou R; Conte A; Liu T; Farjo M; Walden KKO; Rendon G; Fields CJ; Wang L; Fredrickson R; Edmonson DC; Baughman ME; Chiu KK; Choi H; Scardina KR; Bradley S; Gloss SL; Reinhart C; Yedetore J; Quicksall J; Owens AN; Broach J; Barton B; Lazar P; Heetderks WJ; Robinson ML; Mostafa HH; Manabe YC; Pekosz A; McManus DD; Brooke CB Nat Microbiol 2022[May]; 7 (5): 640-652 PMID35484231show ga The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly understood. We captured the dynamics of infectious virus and viral RNA shedding during acute infection through daily longitudinal sampling of 60 individuals for up to 14 days. By fitting mechanistic models, we directly estimated viral expansion and clearance rates and overall infectiousness for each individual. Significant person-to-person variation in infectious virus shedding suggests that individual-level heterogeneity in viral dynamics contributes to 'superspreading'. Viral genome loads often peaked days earlier in saliva than in nasal swabs, indicating strong tissue compartmentalization and suggesting that saliva may serve as a superior sampling site for early detection of infection. Viral loads and clearance kinetics of Alpha (B.1.1.7) and previously circulating non-variant-of-concern viruses were mostly indistinguishable, indicating that the enhanced transmissibility of this variant cannot be explained simply by higher viral loads or delayed clearance. These results provide a high-resolution portrait of SARS-CoV-2 infection dynamics and implicate individual-level heterogeneity in infectiousness in superspreading. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Viral Load[MESH]Daily longitudinal sampling of SARS-CoV-2 infection reveals substantia(epmc).pdf DeepDyve Pubget Overpricing