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10.1038/s41598-022-10516-1 http://scihub22266oqcxt.onion/10.1038/s41598-022-10516-1 35477940!9043882!35477940     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35477940&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35477940.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2022 ; 12 (1): 6851 Nephropedia Template TP {{tp|p=35477940|t=2022. Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease |pdf=|usr=}}{{35477940}} gab.com Text Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35477940 #FOAvip COVID-19 is associated with an increased risk of thrombotic events. However, the pathogenesis of these complications is unclear and reports on platelet infection and activation by the virus are conflicting. Here, we integrated single-cell transcriptomic data to elucidate whether platelet activation is a specific response to SARS-CoV-2 infection or a consequence of a generalized inflammatory state. Although platelets from patients infected with SARS-CoV-2 over expressed genes involved in activation and aggregation when compared to healthy controls; those differences disappeared when the comparison was made with patients with generalized inflammatory conditions of other etiology than COVID-19. The membrane receptor for the virus, ACE-2, was not expressed by infected or control platelets. Our results suggest that platelet activation in patients with severe COVID-19 is mainly a consequence of a systemic inflammatory state than direct invasion and activation. Twit Text FOAVip Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=35477940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35477940 #FOAvip English Wikipedia <ref>{{Cite pmid|35477940}}</ref> Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease #MMPMID35477940 Garma LD; Deng H; Goldschmidt E Sci Rep 2022[Apr]; 12 (1): 6851 PMID35477940show ga COVID-19 is associated with an increased risk of thrombotic events. However, the pathogenesis of these complications is unclear and reports on platelet infection and activation by the virus are conflicting. Here, we integrated single-cell transcriptomic data to elucidate whether platelet activation is a specific response to SARS-CoV-2 infection or a consequence of a generalized inflammatory state. Although platelets from patients infected with SARS-CoV-2 over expressed genes involved in activation and aggregation when compared to healthy controls; those differences disappeared when the comparison was made with patients with generalized inflammatory conditions of other etiology than COVID-19. The membrane receptor for the virus, ACE-2, was not expressed by infected or control platelets. Our results suggest that platelet activation in patients with severe COVID-19 is mainly a consequence of a systemic inflammatory state than direct invasion and activation. |*Blood Platelets[MESH] |*COVID-19/genetics[MESH] |Humans[MESH] |Platelet Activation/genetics[MESH] |SARS-CoV-2[MESH]Integrated analysis of transcriptomic data reveals the platelet respon(epmc).pdf DeepDyve Pubget Overpricing