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10.1016/j.celrep.2022.110744 http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.110744 35477000!9040432!35477000     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35477000.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2022 ; 39 (4): 110744 Nephropedia Template TP {{tp|p=35477000|t=2022. Characterization and functional interrogation of the SARS-CoV-2 RNA interactome |pdf=|usr=}}{{35477000}} gab.com Text Characterization and functional interrogation of the SARS-CoV-2 RNA interactome JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35477000 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic, which has led to a devastating global health crisis. The emergence of variants that escape neutralizing responses emphasizes the urgent need to deepen our understanding of SARS-CoV-2 biology. Using a comprehensive identification of RNA-binding proteins (RBPs) by mass spectrometry (ChIRP-MS) approach, we identify 107 high-confidence cellular factors that interact with the SARS-CoV-2 genome during infection. By systematically knocking down their expression in human lung epithelial cells, we find that the majority of the identified RBPs are SARS-CoV-2 proviral factors. In particular, we show that HNRNPA2B1, ILF3, QKI, and SFPQ interact with the SARS-CoV-2 genome and promote viral RNA amplification. Our study provides valuable resources for future investigations into the mechanisms of SARS-CoV-2 replication and the identification of host-centered antiviral therapies. Twit Text FOAVip Characterization and functional interrogation of the SARS-CoV-2 RNA interactome ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35477000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35477000 #FOAvip English Wikipedia <ref>{{Cite pmid|35477000}}</ref> Characterization and functional interrogation of the SARS-CoV-2 RNA interactome #MMPMID35477000 Labeau A; Fery-Simonian L; Lefevre-Utile A; Pourcelot M; Bonnet-Madin L; Soumelis V; Lotteau V; Vidalain PO; Amara A; Meertens L Cell Rep 2022[Apr]; 39 (4): 110744 PMID35477000show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic, which has led to a devastating global health crisis. The emergence of variants that escape neutralizing responses emphasizes the urgent need to deepen our understanding of SARS-CoV-2 biology. Using a comprehensive identification of RNA-binding proteins (RBPs) by mass spectrometry (ChIRP-MS) approach, we identify 107 high-confidence cellular factors that interact with the SARS-CoV-2 genome during infection. By systematically knocking down their expression in human lung epithelial cells, we find that the majority of the identified RBPs are SARS-CoV-2 proviral factors. In particular, we show that HNRNPA2B1, ILF3, QKI, and SFPQ interact with the SARS-CoV-2 genome and promote viral RNA amplification. Our study provides valuable resources for future investigations into the mechanisms of SARS-CoV-2 replication and the identification of host-centered antiviral therapies. |*COVID-19/genetics[MESH] |*RNA, Viral/genetics[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics[MESH]Characterization and functional interrogation of the SARS-CoV-2 RNA in(epmc).pdf DeepDyve Pubget Overpricing