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10.1161/JAHA.121.024393

http://scihub22266oqcxt.onion/10.1161/JAHA.121.024393
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35475362!9238597!35475362
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suck abstract from ncbi


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pmid35475362      J+Am+Heart+Assoc 2022 ; 11 (9): e024393
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  • Comparison of Multisystem Inflammatory Syndrome in Children-Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vaccine-Related Myocarditis in Children #MMPMID35475362
  • Patel T; Kelleman M; West Z; Peter A; Dove M; Butto A; Oster ME
  • J Am Heart Assoc 2022[May]; 11 (9): e024393 PMID35475362show ga
  • Background Although rare, classic viral myocarditis in the pediatric population is a disease that carries significant morbidity and mortality. Since 2020, myocarditis has been a common component of multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection. In 2021, myocarditis related to mRNA COVID-19 vaccines was recognized as a rare adverse event. This study aims to compare classic, MIS-C, and COVID-19 vaccine-related myocarditis with regard to clinical presentation, course, and outcomes. Methods and Results In this retrospective cohort study, we compared patients aged <21 years hospitalized at our institution with classic viral myocarditis from 2015 to 2019, MIS-C myocarditis from March 2020 to February 2021, and vaccine-related myocarditis from May 2021 to June 2021. Of 201 total participants, 43 patients had classic myocarditis, 149 had MIS-C myocarditis, and 9 had vaccine-related myocarditis. At presentation, ejection fraction was lowest for those with classic myocarditis, with ejection fraction <55% present in 58% of patients. Nearly all patients with MIS-C myocarditis (n=139, 93%) and all patients with vaccine-related myocarditis (n=9, 100%) had normal left ventricular ejection fraction at the time of discharge compared with 70% (n=30) of the classic myocarditis group (P<0.001). At 3 months after discharge, of the 21 children discharged with depressed ejection fraction, none of the 10 children with MIS-C myocarditis had residual dysfunction compared with 3 of the 11 (27%) patients in the classic myocarditis group. Conclusions Compared with classic myocarditis, those with MIS-C myocarditis had better clinical outcomes, including rapid recovery of cardiac function. Patients with vaccine-related myocarditis had prompt resolution of symptoms and improvement of cardiac function.
  • |*COVID-19/complications/diagnosis/prevention & control[MESH]
  • |*Myocarditis/chemically induced/diagnosis/epidemiology[MESH]
  • |COVID-19 Vaccines/adverse effects[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Stroke Volume[MESH]
  • |Systemic Inflammatory Response Syndrome[MESH]


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