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10.1016/j.imu.2022.100951 http://scihub22266oqcxt.onion/10.1016/j.imu.2022.100951 35475214!9020503!35475214     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inform+Med+Unlocked 2022 ; 30 (ä): 100951 Nephropedia Template TP {{tp|p=35475214|t=2022. Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach |pdf=|usr=}}{{35475214}} gab.com Text Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach JO: Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=35475214 #FOAvip The new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the etiological agent of Coronavirus disease 2019 (COVID-19), which becomes an eventual pandemic outbreak. Lack of proper therapeutic management has accelerated the researchers to repurpose existing drugs with known preclinical and toxicity profiles, which can easily enter Phase 3 or 4 or can be used directly in clinical settings. Vitamins are necessary nutrients for cell growth, function, and development. Furthermore, they play an important role in pathogen defence via cell-mediated responses and boost immunity. Using a computational approach, we intend to identify the probable inhibitory effect of all vitamins on the drug targets of COVID-19. The computational analysis demonstrated that vitamin B12 resulted in depicting suitable significant binding with furin, RNA dependent RNA polymerase (RdRp), Main proteases (Mpro), ORF3a and ORF7a and Vitamin D3 with spike protein and vitamin B9 with non structural protein 3 (NSP3). A detailed examination of vitamins suggests that vitamin B12 may be the component that reduces virulence by blocking furin which is responsible for entry of virus in the host cell. Details from the Molecular Dynamics (MD) simulation study aided in determining vitamin B12 as a possible furin inhibitor. Twit Text FOAVip Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach ????Inform Med Unlocked http://www.kidney.de/pget.php?&tw=1&pmid=35475214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35475214 #FOAvip English Wikipedia <ref>{{Cite pmid|35475214}}</ref> Unravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A computational approach #MMPMID35475214 Pandya M; Shah S; M D; Juneja T; Patel A; Gadnayak A; Dave S; Das K; Das J Inform Med Unlocked 2022[]; 30 (ä): 100951 PMID35475214show ga The new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the etiological agent of Coronavirus disease 2019 (COVID-19), which becomes an eventual pandemic outbreak. Lack of proper therapeutic management has accelerated the researchers to repurpose existing drugs with known preclinical and toxicity profiles, which can easily enter Phase 3 or 4 or can be used directly in clinical settings. Vitamins are necessary nutrients for cell growth, function, and development. Furthermore, they play an important role in pathogen defence via cell-mediated responses and boost immunity. Using a computational approach, we intend to identify the probable inhibitory effect of all vitamins on the drug targets of COVID-19. The computational analysis demonstrated that vitamin B12 resulted in depicting suitable significant binding with furin, RNA dependent RNA polymerase (RdRp), Main proteases (Mpro), ORF3a and ORF7a and Vitamin D3 with spike protein and vitamin B9 with non structural protein 3 (NSP3). A detailed examination of vitamins suggests that vitamin B12 may be the component that reduces virulence by blocking furin which is responsible for entry of virus in the host cell. Details from the Molecular Dynamics (MD) simulation study aided in determining vitamin B12 as a possible furin inhibitor. äUnravelling Vitamin B12 as a potential inhibitor against SARS-CoV-2: A(epmc).pdf DeepDyve Pubget Overpricing