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10.1016/j.xcrm.2022.100557 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2022.100557 35474751!8895494!35474751     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2022 ; 3 (3): 100557 Nephropedia Template TP {{tp|p=35474751|t=2022. Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections |pdf=|usr=}}{{35474751}} gab.com Text Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=35474751 #FOAvip Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses. These peak by the time the virus is first detected and sometimes precede virus detection. Cell proliferation is most evident in CD8 T cells and associated with specific expansion of SARS-CoV-2-reactive TCRs, in contrast to virus-specific antibodies, which lag by 1-2 weeks. Our data support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines. Twit Text FOAVip Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=35474751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35474751 #FOAvip English Wikipedia <ref>{{Cite pmid|35474751}}</ref> Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections #MMPMID35474751 Chandran A; Rosenheim J; Nageswaran G; Swadling L; Pollara G; Gupta RK; Burton AR; Guerra-Assuncao JA; Woolston A; Ronel T; Pade C; Gibbons JM; Sanz-Magallon Duque De Estrada B; Robert de Massy M; Whelan M; Semper A; Brooks T; Altmann DM; Boyton RJ; McKnight A; Captur G; Manisty C; Treibel TA; Moon JC; Tomlinson GS; Maini MK; Chain BM; Noursadeghi M Cell Rep Med 2022[Mar]; 3 (3): 100557 PMID35474751show ga Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses. These peak by the time the virus is first detected and sometimes precede virus detection. Cell proliferation is most evident in CD8 T cells and associated with specific expansion of SARS-CoV-2-reactive TCRs, in contrast to virus-specific antibodies, which lag by 1-2 weeks. Our data support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines. |*COVID-19[MESH] |*Interferon Type I[MESH] |CD8-Positive T-Lymphocytes[MESH] |Flow Cytometry[MESH] |Humans[MESH]Rapid synchronous type 1 IFN and virus-specific T cell responses chara(epmc).pdf DeepDyve Pubget Overpricing