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10.15252/embj.2022111208 http://scihub22266oqcxt.onion/10.15252/embj.2022111208 35471700!9108606!35471700     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2022 ; 41 (10): e111208 Nephropedia Template TP {{tp|p=35471700|t=2022. Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19 |pdf=|usr=}}{{35471700}} gab.com Text Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19 JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=35471700 #FOAvip Plasmacytoid dendritic cells (pDC) have the unique ability to rapidly mount high-level antiviral type I interferon (IFN-I) responses during diverse virus infections. In COVID-19 patients, reduced pDC numbers correlate with diminished IFN-I serum levels and enhanced disease severity. However, the molecular mechanisms underlying SARS-CoV-2-mediated pDC stimulation to induce cytokine responses are still largely unclear. In this issue of the EMBO Journal, van der Sluis and colleagues tackled this question by using an innovative hematopoietic stem and progenitor cells (HSPC)-pDC system that allows gene editing and the detailed analysis of pDC sensing mechanisms. Twit Text FOAVip Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19 ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=35471700 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35471700 #FOAvip English Wikipedia <ref>{{Cite pmid|35471700}}</ref> Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19 #MMPMID35471700 Becker J; Kalinke U EMBO J 2022[May]; 41 (10): e111208 PMID35471700show ga Plasmacytoid dendritic cells (pDC) have the unique ability to rapidly mount high-level antiviral type I interferon (IFN-I) responses during diverse virus infections. In COVID-19 patients, reduced pDC numbers correlate with diminished IFN-I serum levels and enhanced disease severity. However, the molecular mechanisms underlying SARS-CoV-2-mediated pDC stimulation to induce cytokine responses are still largely unclear. In this issue of the EMBO Journal, van der Sluis and colleagues tackled this question by using an innovative hematopoietic stem and progenitor cells (HSPC)-pDC system that allows gene editing and the detailed analysis of pDC sensing mechanisms. |*COVID-19[MESH] |*Interferon Type I[MESH] |*Toll-Like Receptors[MESH] |Dendritic Cells[MESH] |Humans[MESH]Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing