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10.1007/s10787-022-00988-y http://scihub22266oqcxt.onion/10.1007/s10787-022-00988-y 35471628!9040700!35471628     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inflammopharmacology 2022 ; 30 (3): 811-820 Nephropedia Template TP {{tp|p=35471628|t=2022. High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons |pdf=|usr=}}{{35471628}} gab.com Text High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons JO: Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=35471628 #FOAvip High-mobility group box 1 (HMGB1), a multifunctional nuclear protein, exists mainly within the nucleus of all mammal eukaryotic cells. It is actively secreted by the necrotic cells as a response to the inflammatory signaling pathway. HMGB1 binds to receptor ligands as RAGE, and TLR and becomes a pro-inflammatory cytokine with a robust capacity to trigger inflammatory response. It is a critical mediator of the pathogenesis of systemic inflammation in numerous inflammatory disorders. Release of HMGB1 is associated with different viral infections and strongly participates in the regulation of viral replication cycles. In COVID-19 era, high HMGB1 serum levels were observed in COVID-19 patients and linked with the disease severity, development of cytokine storm (CS), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). SARS-CoV-2-induced cytolytic effect may encourage release of HMGB1 due to nuclear damage. Besides, HMGB1 activates release of pro-inflammatory cytokines from immune cells and up-regulation of angiotensin I-converting enzyme 2 (ACE2). Therefore, targeting of the HMGB1 pathway by anti-HMGB1 agents, such as heparin, resveratrol and metformin, may decrease COVID-19 severity. HMGB1 signaling pathway has noteworthy role in the pathogenesis of SARS-CoV-2 infections and linked with development of ALI and ARDS in COVID-19 patients. Different endogenous and exogenous agents may affect release and activation of HMGB1 pathway. Targeting of HMGB1-mediated TLR2/TLR4, RAGE and MAPK signaling, might be a new promising drug candidate against development of ALI and/or ARDS in severely affected COVID-19 patients. Twit Text FOAVip High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons ????Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=35471628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35471628 #FOAvip English Wikipedia <ref>{{Cite pmid|35471628}}</ref> High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons #MMPMID35471628 Al-Kuraishy HM; Al-Gareeb AI; Alkazmi L; Habotta OA; Batiha GE Inflammopharmacology 2022[Jun]; 30 (3): 811-820 PMID35471628show ga High-mobility group box 1 (HMGB1), a multifunctional nuclear protein, exists mainly within the nucleus of all mammal eukaryotic cells. It is actively secreted by the necrotic cells as a response to the inflammatory signaling pathway. HMGB1 binds to receptor ligands as RAGE, and TLR and becomes a pro-inflammatory cytokine with a robust capacity to trigger inflammatory response. It is a critical mediator of the pathogenesis of systemic inflammation in numerous inflammatory disorders. Release of HMGB1 is associated with different viral infections and strongly participates in the regulation of viral replication cycles. In COVID-19 era, high HMGB1 serum levels were observed in COVID-19 patients and linked with the disease severity, development of cytokine storm (CS), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). SARS-CoV-2-induced cytolytic effect may encourage release of HMGB1 due to nuclear damage. Besides, HMGB1 activates release of pro-inflammatory cytokines from immune cells and up-regulation of angiotensin I-converting enzyme 2 (ACE2). Therefore, targeting of the HMGB1 pathway by anti-HMGB1 agents, such as heparin, resveratrol and metformin, may decrease COVID-19 severity. HMGB1 signaling pathway has noteworthy role in the pathogenesis of SARS-CoV-2 infections and linked with development of ALI and ARDS in COVID-19 patients. Different endogenous and exogenous agents may affect release and activation of HMGB1 pathway. Targeting of HMGB1-mediated TLR2/TLR4, RAGE and MAPK signaling, might be a new promising drug candidate against development of ALI and/or ARDS in severely affected COVID-19 patients. |*Acute Lung Injury/metabolism[MESH] |*COVID-19 Drug Treatment[MESH] |*HMGB1 Protein/metabolism[MESH] |*Respiratory Distress Syndrome/drug therapy[MESH] |Animals[MESH] |Cytokine Release Syndrome[MESH] |Cytokines[MESH] |Humans[MESH] |Mammals/metabolism[MESH]High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of danger(epmc).pdf DeepDyve Pubget Overpricing