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10.26508/lsa.202101347 http://scihub22266oqcxt.onion/10.26508/lsa.202101347 35470238!9039346!35470238     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35470238.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Life+Sci+Alliance 2022 ; 5 (8): ä Nephropedia Template TP {{tp|p=35470238|t=2022. Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption |pdf=|usr=}}{{35470238}} gab.com Text Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption JO: Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=35470238 #FOAvip Fundamental to viral biology is identification and annotation of viral genes and their function. Determining the level of coronavirus gene expression is inherently difficult due to the positive stranded RNA genome and the identification of subgenomic RNAs (sgRNAs) that are required for expression of most viral genes. We developed a bioinformatic pipeline to analyze metatranscriptomic data from 20 independent studies encompassing 588 individual samples and 10 coronavirus species. This comparative analysis defined a core sgRNA repertoire for SARS-CoV-2 and found novel sgRNAs that could encode functional short peptides. Relevant to coronavirus infectivity and transmission, we also observed that the ratio of Spike sgRNA to Nucleocapsid one is highest in SARS-CoV-2, among the beta-coronaviruses examined. Furthermore, the adjustment of this ratio can be made by modifications to the viral RNA replication machinery, representing a form of viral gene regulation that may be involved in host adaption. Twit Text FOAVip Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption ????Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=35470238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35470238 #FOAvip English Wikipedia <ref>{{Cite pmid|35470238}}</ref> Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption #MMPMID35470238 Lyu L; Feng R; Zhang M; Xie X; Liao Y; Zhou Y; Guo X; Su B; Dorsett Y; Chen L Life Sci Alliance 2022[Aug]; 5 (8): ä PMID35470238show ga Fundamental to viral biology is identification and annotation of viral genes and their function. Determining the level of coronavirus gene expression is inherently difficult due to the positive stranded RNA genome and the identification of subgenomic RNAs (sgRNAs) that are required for expression of most viral genes. We developed a bioinformatic pipeline to analyze metatranscriptomic data from 20 independent studies encompassing 588 individual samples and 10 coronavirus species. This comparative analysis defined a core sgRNA repertoire for SARS-CoV-2 and found novel sgRNAs that could encode functional short peptides. Relevant to coronavirus infectivity and transmission, we also observed that the ratio of Spike sgRNA to Nucleocapsid one is highest in SARS-CoV-2, among the beta-coronaviruses examined. Furthermore, the adjustment of this ratio can be made by modifications to the viral RNA replication machinery, representing a form of viral gene regulation that may be involved in host adaption. |*COVID-19/genetics[MESH] |*SARS-CoV-2/genetics[MESH] |Gene Expression Regulation, Viral[MESH] |Humans[MESH] |RNA, Viral/genetics[MESH]Subgenomic RNA profiling suggests novel mechanism in coronavirus gene (epmc).pdf DeepDyve Pubget Overpricing