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10.1111/jfbc.14212

http://scihub22266oqcxt.onion/10.1111/jfbc.14212
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35467022!9114900!35467022
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suck abstract from ncbi


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pmid35467022      J+Food+Biochem 2022 ; 46 (9): e14212
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  • Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2? #MMPMID35467022
  • Khezri MR; Ghasemnejad-Berenji M; Moloodsouri D
  • J Food Biochem 2022[Sep]; 46 (9): e14212 PMID35467022show ga
  • Hesperetin, mainly found in citrus honey, has antioxidant, anti-inflammatory, and antiviral properties. Recently, the effect of hesperetin on different aspects of SARS-CoV-2 infection such as viral entry, replication, and inflammatory responses has attracted a lot of attention. However, the exact molecular mechanism for its effects on SARS-CoV-2 infection is not stated. The PI3K/AKT signaling pathway is an intracellular pathway involved in cell proliferation, protein synthesis, and response to environmental changes. Since the role of this pathway in the pathogenesis of SARS-CoV-2 has recently been considered, this letter assumes the probable role of this pathway in the function of hesperetin against SARS-CoV-2 infection. PRACTICAL APPLICATIONS: In this paper, we have discussed the therapeutic effects of hesperetin on SARS-CoV-2 infection. Additionally, we have hypothesized the molecular mechanism of hesperetin in suppression of SARS-CoV-2 entry to the host cells, its replication and inhibition of inflammatory responses. Based on this evidence, the pharmacological properties of hesperetin make this natural compound a potential treatment for suppression of SARS-CoV-2 entry into host cells and the subsequent replication of viral particles.
  • |*COVID-19 Drug Treatment[MESH]
  • |*SARS-CoV-2[MESH]
  • |Hesperidin[MESH]
  • |Humans[MESH]
  • |Phosphatidylinositol 3-Kinases/genetics[MESH]


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