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10.1186/s40168-022-01260-9 http://scihub22266oqcxt.onion/10.1186/s40168-022-01260-9 35459226!9024070!35459226     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiome 2022 ; 10 (1): 65 Nephropedia Template TP {{tp|p=35459226|t=2022. Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology |pdf=|usr=}}{{35459226}} gab.com Text Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology JO: Microbiome http://www.kidney.de/pget.php?&tw=1&pmid=35459226 #FOAvip BACKGROUND: Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, the mechanisms involved in the progression to severity are poorly understood. METHODS: The virome of tracheal aspirates (TA) from 25 COVID-19 patients under IMV was assessed through unbiased RNA sequencing (RNA-seq), and correlation analyses were conducted using available clinical data. Unbiased sequences from nasopharyngeal swabs (NS) from mild cases and TA from non-COVID patients were included in our study for further comparisons. RESULTS: We found higher levels and differential expression of human endogenous retrovirus K (HERV-K) genes in TA from critically ill and deceased patients when comparing nasopharyngeal swabs from mild cases to TA from non-COVID patients. In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days of diagnosis) in the intensive care unit. Increased HERV-K expression in deceased patients was associated with IL-17-related inflammation, monocyte activation, and an increased consumption of clotting/fibrinolysis factors. Moreover, increased HERV-K expression was detected in human primary monocytes from healthy donors after experimental SARS-CoV-2 infection in vitro. CONCLUSION: Our data implicate the levels of HERV-K transcripts in the physiopathology of COVID-19 in the respiratory tract of patients under invasive mechanical ventilation. Video abstract. Twit Text FOAVip Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology ????Microbiome http://www.kidney.de/pget.php?&tw=1&pmid=35459226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35459226 #FOAvip English Wikipedia <ref>{{Cite pmid|35459226}}</ref> Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology #MMPMID35459226 Temerozo JR; Fintelman-Rodrigues N; Dos Santos MC; Hottz ED; Sacramento CQ; de Paula Dias da Silva A; Mandacaru SC; Dos Santos Moraes EC; Trugilho MRO; Gesto JSM; Ferreira MA; Saraiva FB; Palhinha L; Martins-Goncalves R; Azevedo-Quintanilha IG; Abrantes JL; Righy C; Kurtz P; Jiang H; Tan H; Morel C; Bou-Habib DC; Bozza FA; Bozza PT; Souza TML Microbiome 2022[Apr]; 10 (1): 65 PMID35459226show ga BACKGROUND: Critically ill 2019 coronavirus disease (COVID-19) patients under invasive mechanical ventilation (IMV) are 10 to 40 times more likely to die than the general population. Although progression from mild to severe COVID-19 has been associated with hypoxia, uncontrolled inflammation, and coagulopathy, the mechanisms involved in the progression to severity are poorly understood. METHODS: The virome of tracheal aspirates (TA) from 25 COVID-19 patients under IMV was assessed through unbiased RNA sequencing (RNA-seq), and correlation analyses were conducted using available clinical data. Unbiased sequences from nasopharyngeal swabs (NS) from mild cases and TA from non-COVID patients were included in our study for further comparisons. RESULTS: We found higher levels and differential expression of human endogenous retrovirus K (HERV-K) genes in TA from critically ill and deceased patients when comparing nasopharyngeal swabs from mild cases to TA from non-COVID patients. In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days of diagnosis) in the intensive care unit. Increased HERV-K expression in deceased patients was associated with IL-17-related inflammation, monocyte activation, and an increased consumption of clotting/fibrinolysis factors. Moreover, increased HERV-K expression was detected in human primary monocytes from healthy donors after experimental SARS-CoV-2 infection in vitro. CONCLUSION: Our data implicate the levels of HERV-K transcripts in the physiopathology of COVID-19 in the respiratory tract of patients under invasive mechanical ventilation. Video abstract. |*COVID-19[MESH] |*Endogenous Retroviruses/genetics[MESH] |Critical Illness[MESH] |Humans[MESH] |Inflammation[MESH] |Respiratory System[MESH]Human endogenous retrovirus K in the respiratory tract is associated w(epmc).pdf DeepDyve Pubget Overpricing