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10.3390/jcm11082093

http://scihub22266oqcxt.onion/10.3390/jcm11082093
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35456186!9024702!35456186
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suck abstract from ncbi


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pmid35456186      J+Clin+Med 2022 ; 11 (8): ä
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  • Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome #MMPMID35456186
  • Chiumello D; Pozzi T; Fratti I; Modafferi L; Montante M; Papa GFS; Coppola S
  • J Clin Med 2022[Apr]; 11 (8): ä PMID35456186show ga
  • Our aim was to investigate the distribution of acid-base disorders in patients with COVID-19 ARDS using both the Henderson-Hasselbalch and Stewart's approach and to explore if hypoxemia can influence acid-base disorders. COVID-19 ARDS patients, within the first 48 h of the need for a non-invasive respiratory support, were retrospectively enrolled. Respiratory support was provided by helmet continuous positive airway pressure (CPAP) or by non-invasive ventilation. One hundred and four patients were enrolled, 84% treated with CPAP and 16% with non-invasive ventilation. Using the Henderson-Hasselbalch approach, 40% and 32% of patients presented respiratory and metabolic alkalosis, respectively; 13% did not present acid-base disorders. Using Stewart's approach, 43% and 33% had a respiratory and metabolic alkalosis, respectively; 12% of patients had a mixed disorder characterized by normal pH with a lower SID. The severe hypoxemic and moderate hypoxemic group presented similar frequencies of respiratory and metabolic alkalosis. The most frequent acid-base disorders were respiratory and metabolic alkalosis using both the Henderson-Hasselbalch and Stewart's approach. Stewart's approach detected mixed disorders with a normal pH probably generated by the combined effect of strong ions and weak acids. The impairment of oxygenation did not affect acid-base disorders.
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