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10.3390/biomedicines10040818 http://scihub22266oqcxt.onion/10.3390/biomedicines10040818 35453568!9030375!35453568     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomedicines 2022 ; 10 (4): ä Nephropedia Template TP {{tp|p=35453568|t=2022. Molecular Mechanism of Pancreatic beta-Cell Failure in Type 2 Diabetes Mellitus |pdf=|usr=}}{{35453568}} gab.com Text Molecular Mechanism of Pancreatic beta-Cell Failure in Type 2 Diabetes Mellitus JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=35453568 #FOAvip Various important transcription factors in the pancreas are involved in the process of pancreas development, the differentiation of endocrine progenitor cells into mature insulin-producing pancreatic beta-cells and the preservation of mature beta-cell function. However, when beta-cells are continuously exposed to a high glucose concentration for a long period of time, the expression levels of several insulin gene transcription factors are substantially suppressed, which finally leads to pancreatic beta-cell failure found in type 2 diabetes mellitus. Here we show the possible underlying pathway for beta-cell failure. It is likely that reduced expression levels of MafA and PDX-1 and/or incretin receptor in beta-cells are closely associated with beta-cell failure in type 2 diabetes mellitus. Additionally, since incretin receptor expression is reduced in the advanced stage of diabetes mellitus, incretin-based medicines show more favorable effects against beta-cell failure, especially in the early stage of diabetes mellitus compared to the advanced stage. On the other hand, many subjects have recently suffered from life-threatening coronavirus infection, and coronavirus infection has brought about a new and persistent pandemic. Additionally, the spread of coronavirus infection has led to various limitations on the activities of daily life and has restricted economic development worldwide. It has been reported recently that SARS-CoV-2 directly infects beta-cells through neuropilin-1, leading to apoptotic beta-cell death and a reduction in insulin secretion. In this review article, we feature a possible molecular mechanism for pancreatic beta-cell failure, which is often observed in type 2 diabetes mellitus. Finally, we are hopeful that coronavirus infection will decline and normal daily life will soon resume all over the world. Twit Text FOAVip Molecular Mechanism of Pancreatic beta-Cell Failure in Type 2 Diabetes Mellitus ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=35453568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35453568 #FOAvip English Wikipedia <ref>{{Cite pmid|35453568}}</ref> Molecular Mechanism of Pancreatic beta-Cell Failure in Type 2 Diabetes Mellitus #MMPMID35453568 Kaneto H; Kimura T; Shimoda M; Obata A; Sanada J; Fushimi Y; Matsuoka TA; Kaku K Biomedicines 2022[Mar]; 10 (4): ä PMID35453568show ga Various important transcription factors in the pancreas are involved in the process of pancreas development, the differentiation of endocrine progenitor cells into mature insulin-producing pancreatic beta-cells and the preservation of mature beta-cell function. However, when beta-cells are continuously exposed to a high glucose concentration for a long period of time, the expression levels of several insulin gene transcription factors are substantially suppressed, which finally leads to pancreatic beta-cell failure found in type 2 diabetes mellitus. Here we show the possible underlying pathway for beta-cell failure. It is likely that reduced expression levels of MafA and PDX-1 and/or incretin receptor in beta-cells are closely associated with beta-cell failure in type 2 diabetes mellitus. Additionally, since incretin receptor expression is reduced in the advanced stage of diabetes mellitus, incretin-based medicines show more favorable effects against beta-cell failure, especially in the early stage of diabetes mellitus compared to the advanced stage. On the other hand, many subjects have recently suffered from life-threatening coronavirus infection, and coronavirus infection has brought about a new and persistent pandemic. Additionally, the spread of coronavirus infection has led to various limitations on the activities of daily life and has restricted economic development worldwide. It has been reported recently that SARS-CoV-2 directly infects beta-cells through neuropilin-1, leading to apoptotic beta-cell death and a reduction in insulin secretion. In this review article, we feature a possible molecular mechanism for pancreatic beta-cell failure, which is often observed in type 2 diabetes mellitus. Finally, we are hopeful that coronavirus infection will decline and normal daily life will soon resume all over the world. äMolecular Mechanism of Pancreatic beta-Cell Failure in Type 2 Diabetes(epmc).pdf DeepDyve Pubget Overpricing