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10.1182/bloodadvances.2021006728 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2021006728 35452514!9040505!35452514     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35452514.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Adv 2022 ; 6 (12): 3697-3702 Nephropedia Template TP {{tp|p=35452514|t=2022. Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis |pdf=|usr=}}{{35452514}} gab.com Text Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=35452514 #FOAvip Immune complexes form in systemic disorders such as rheumatological, autoimmune, and allergic diseases or in response to infections or medications. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccines have been associated with rare yet serious thrombotic complications in the brain due to the formation of immune complexes that activate platelets. There are currently no data visualizing the interplay of platelets with leukocytes and the brain vasculature endothelium in response to immune complexes. This is in part due to the absence of FcgammaRIIA in mice, a receptor for immune complexes implicated in these thrombotic incidents. Here, we describe and illustrate events at the cellular level that take place in the brain vasculature in response to systemic administration of surrogate immune complexes. We used Ly6gCre+/-::Rosa26-TdT+/-::CD41-YFP+/- mice expressing the FcgammaRIIA transgene and fluorescence in neutrophils and platelets. Using real-time videomicroscopy to capture high-velocity events in conjunction with unbiased computer-assisted analyses, we provide images and quantifications of the cellular responses downstream of FcgammaRIIA stimulation. We observed transient and stable platelet-neutrophil interactions, platelets forming thrombi, and neutrophil adhesion to blood vessel walls. This imaging approach in a quadruple transgenic animal model can be used for the study of the pathogenic roles of immune complexes in disease. Twit Text FOAVip Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=35452514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35452514 #FOAvip English Wikipedia <ref>{{Cite pmid|35452514}}</ref> Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis #MMPMID35452514 Laroche A; Soulet D; Bazin M; Levesque T; Allaeys I; Vallieres N; Gunzer M; Flamand L; Lacroix S; Boilard E Blood Adv 2022[Jun]; 6 (12): 3697-3702 PMID35452514show ga Immune complexes form in systemic disorders such as rheumatological, autoimmune, and allergic diseases or in response to infections or medications. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adenoviral vector vaccines have been associated with rare yet serious thrombotic complications in the brain due to the formation of immune complexes that activate platelets. There are currently no data visualizing the interplay of platelets with leukocytes and the brain vasculature endothelium in response to immune complexes. This is in part due to the absence of FcgammaRIIA in mice, a receptor for immune complexes implicated in these thrombotic incidents. Here, we describe and illustrate events at the cellular level that take place in the brain vasculature in response to systemic administration of surrogate immune complexes. We used Ly6gCre+/-::Rosa26-TdT+/-::CD41-YFP+/- mice expressing the FcgammaRIIA transgene and fluorescence in neutrophils and platelets. Using real-time videomicroscopy to capture high-velocity events in conjunction with unbiased computer-assisted analyses, we provide images and quantifications of the cellular responses downstream of FcgammaRIIA stimulation. We observed transient and stable platelet-neutrophil interactions, platelets forming thrombi, and neutrophil adhesion to blood vessel walls. This imaging approach in a quadruple transgenic animal model can be used for the study of the pathogenic roles of immune complexes in disease. |*COVID-19[MESH] |*Thrombosis[MESH] |Animals[MESH] |Antigen-Antibody Complex[MESH] |Blood Platelets/pathology[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Neutrophils[MESH]Live imaging of platelets and neutrophils during antibody-mediated neu(epmc).pdf DeepDyve Pubget Overpricing