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10.1093/jmcb/mjac021 http://scihub22266oqcxt.onion/10.1093/jmcb/mjac021 35451490!9384834!35451490     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35451490.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Cell+Biol 2022 ; 14 (4): ä Nephropedia Template TP {{tp|p=35451490|t=2022. SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients |pdf=|usr=}}{{35451490}} gab.com Text SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35451490 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and prognosis of disease severity outcome. Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, it is still unclear whether direct SARS-CoV-2 infection of immune cells could also play a role in this scenario by harboring viral replication. We found that monocytes, as well as both B and T lymphocytes, were susceptible to SARS-CoV-2 infection in vitro, accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis. In addition, flow cytometry and immunofluorescence analysis revealed that SARS-CoV-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019 (COVID-19) patients. The rates of SARS-CoV-2-infected monocytes in peripheral blood mononuclear cells from COVID-19 patients increased over time from symptom onset, with SARS-CoV-2-positive monocytes, B cells, and CD4+ T lymphocytes also detected in postmortem lung tissue. These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in COVID-19 patients might have important implications for disease pathogenesis and progression, immune dysfunction, and virus spread within the host. Twit Text FOAVip SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=35451490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35451490 #FOAvip English Wikipedia <ref>{{Cite pmid|35451490}}</ref> SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients #MMPMID35451490 Pontelli MC; Castro IA; Martins RB; La Serra L; Veras FP; Nascimento DC; Silva CM; Cardoso RS; Rosales R; Gomes R; Lima TM; Souza JP; Vitti BC; Caetite DB; de Lima MHF; Stumpf SD; Thompson CE; Bloyet LM; Toller-Kawahisa JE; Giannini MC; Bonjorno LP; Lopes MIF; Batah SS; Siyuan L; Luppino-Assad R; Almeida SCL; Oliveira FR; Benatti MN; Pontes LLF; Santana RC; Vilar FC; Auxiliadora-Martins M; Shi PY; Cunha TM; Calado RT; Alves-Filho JC; Zamboni DS; Fabro AT; Louzada-Junior P; Oliveira RDR; Whelan SPJ; Cunha FQ; Arruda E J Mol Cell Biol 2022[Aug]; 14 (4): ä PMID35451490show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and prognosis of disease severity outcome. Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion, it is still unclear whether direct SARS-CoV-2 infection of immune cells could also play a role in this scenario by harboring viral replication. We found that monocytes, as well as both B and T lymphocytes, were susceptible to SARS-CoV-2 infection in vitro, accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis. In addition, flow cytometry and immunofluorescence analysis revealed that SARS-CoV-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019 (COVID-19) patients. The rates of SARS-CoV-2-infected monocytes in peripheral blood mononuclear cells from COVID-19 patients increased over time from symptom onset, with SARS-CoV-2-positive monocytes, B cells, and CD4+ T lymphocytes also detected in postmortem lung tissue. These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in COVID-19 patients might have important implications for disease pathogenesis and progression, immune dysfunction, and virus spread within the host. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Cytokine Release Syndrome[MESH] |Humans[MESH] |Leukocytes, Mononuclear[MESH]SARS-CoV-2 productively infects primary human immune system cells in v(epmc).pdf DeepDyve Pubget Overpricing