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10.1002/2211-5463.13414 http://scihub22266oqcxt.onion/10.1002/2211-5463.13414 35445579!9110870!35445579     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2022 ; 12 (9): 1567-1583 Nephropedia Template TP {{tp|p=35445579|t=2022. Recent insights into the structure and function of coronavirus ribonucleases |pdf=|usr=}}{{35445579}} gab.com Text Recent insights into the structure and function of coronavirus ribonucleases JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=35445579 #FOAvip Coronaviruses use approximately two-thirds of their 30-kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS-CoV-2 pandemic has led to renewed interest in the molecular mechanisms used by coronaviruses to infect cells and replicate. Among the 16 Nsps involved in replication and transcription, coronaviruses encode two ribonucleases that process the viral RNA-an exonuclease (Nsp14) and an endonuclease (Nsp15). In this review, we discuss recent structural and biochemical studies of these nucleases and the implications for drug discovery. Twit Text FOAVip Recent insights into the structure and function of coronavirus ribonucleases ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=35445579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35445579 #FOAvip English Wikipedia <ref>{{Cite pmid|35445579}}</ref> Recent insights into the structure and function of coronavirus ribonucleases #MMPMID35445579 Frazier MN; Riccio AA; Wilson IM; Copeland WC; Stanley RE FEBS Open Bio 2022[Sep]; 12 (9): 1567-1583 PMID35445579show ga Coronaviruses use approximately two-thirds of their 30-kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS-CoV-2 pandemic has led to renewed interest in the molecular mechanisms used by coronaviruses to infect cells and replicate. Among the 16 Nsps involved in replication and transcription, coronaviruses encode two ribonucleases that process the viral RNA-an exonuclease (Nsp14) and an endonuclease (Nsp15). In this review, we discuss recent structural and biochemical studies of these nucleases and the implications for drug discovery. |*COVID-19[MESH] |*Viral Nonstructural Proteins/chemistry/genetics/metabolism[MESH] |Humans[MESH] |Mutation[MESH] |Ribonucleases[MESH]Recent insights into the structure and function of coronavirus ribonuc(epmc).pdf DeepDyve Pubget Overpricing